Workshop: Applying exposure science to increase the utility of non-animal data in efficacy and safety testing

  • NC3Rs
Wednesday 15 February 2017 to Thursday 16 February 2017
London

In collaboration with Unilever, the NC3Rs is jointly hosting a two-day workshop in central London on 15-16 February 2017. 

Many of the non-animal approaches currently available can provide useful information on the mechanism of action of drugs and chemicals, which can be used to inform decision-making in product development programmes. However, the utility of data from these approaches can be limited, as exposure considerations are often not taken into account. For example, it is not always clear how the doses tested in in vitro assays relate to concentrations that humans or environmental species would be exposed to in real life situations.  Also, it can be difficult to determine how much of the chemical applied to the model system reaches the site of action (i.e., measured versus nominal or applied concentrations). This can affect interpretation of the effects data. Consideration of exposure within these approaches is necessary to ensure that they generate relevant data that answers the scientific questions. In this way data from non-animal approaches will be more useful for decision-making purposes, and support a reduction in the current reliance on data from animal tests.

The meeting will bring together academic and industry researchers across multiple disciplines to share their knowledge and experiences in applying exposure science to increase the utility of in vitro and in silico data for decision-making, efficacy and safety assessment.  The workshop will be attended by expert scientists from academia, government and regulatory agencies and the (agro)chemicals, consumer products, and pharmaceutical industries.

The key objectives of the workshop are to:

  • Increase awareness and build confidence in the application of exposure-driven approaches to support decision-making based on data from non-animal approaches across sectors;
  • Build a community of scientists working in the area of exposure-driven safety assessment;
  • Identify gaps and challenge areas that need to be addressed to advance the application of exposure science capability;
  • Develop and publish guidance to facilitate the use and wider acceptance of exposure-driven non-animal approaches to inform and improve safety and efficacy decision-making.

Programme

The workshop will be chaired by Professor Alan Boobis OBE, Imperial College London and will showcase new exposure-based approaches which aim to increase the physiological relevance of in vitro assays and computational models, and understanding of human-relevant exposures.  For example, the use of physiologically-based pharmacokinetic (PBPK) mathematical models to predict levels of systemic exposure in humans as well as methods to quantify exposure-response relationships to improve in vitro to in vivo extrapolation.  Discussions will also centre on how confidence can be built in these new approaches to enable their wider use and acceptance in practice.

Confirmed speakers include:

  • Dr Roman Ashauer, University of York, UK
  • Professor Steve Charlton, University of Nottingham, UK
  • Dr Ian Cotgreave, Swetox, Sweden
  • Dr Iain Gardner, Certara/The SimCyp Consortium, UK
  • Professor Beate Escher, UFZ, Germany
  • Professor Gareth Jenkins, Swansea University, UK
  • Dr Nicole Kleinstreuer, NICEATM, USA
  • Professor Nynke Kramer, Utrecht University, Netherlands
  • Professor Philipp Mayer, Technical University of Denmark (DTU), Denmark
  • Dr Bette Meek, University of Ottawa, Canada
  • Dr Alicia Paini, European Commission Joint Research Centre
  • Dr Cecilie Rendal, Unilever, UK
  • Dr Steve Webb, Liverpool John Moores University, UK 
  • Dr Barbara Wetmore, Environmental Protection Agency, USA

Posters

Delegates are encouraged to submit poster abstracts on a topic relevant to the theme of the meeting and highlighting the potential 3Rs benefits. To present a poster, please complete the abstract submission form and submit by 20 January 2017. We will let you know if you have been successful by 27 January 2017.

Registration

Attendance is free, but registration is essential.  The closing date for registration is 23 January 2017.

You will need an NC3Rs website account to register. Please use your institutional email address when registering.