Mini-liver research to reduce animal use in science
3Rs Prize winning research that has for the first time successfully grown "mini-livers" from adult mouse stem cells has won the UK's international prize for the scientific and technological advance with the most potential to replace, reduce or refine the use of animals in science (the 3Rs). Dr Meritxell Huch from Cambridge University's Gurdon Institute, who receives the National Centre for the 3Rs Prize, has developed a method that enables adult mouse stem cells to grow and expand into fully functioning three-dimensional liver tissue. The work was carried out at the Hubrecht Institute in The Netherlands.
Using this method, cells from one mouse could be used to test 1000 drug compounds to treat liver disease, and reduce animal use by up to 50,000.
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