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Mini-liver research to reduce animal use in science

3Rs Prize winning research that has for the first time successfully grown "mini-livers" from adult mouse stem cells has won the UK's international prize for the scientific and technological advance with the most potential to replace, reduce or refine the use of animals in science (the 3Rs). Dr Meritxell Huch from Cambridge University's Gurdon Institute, who receives the National Centre for the 3Rs Prize, has developed a method that enables adult mouse stem cells to grow and expand into fully functioning three-dimensional liver tissue. The work was carried out at the Hubrecht Institute in The Netherlands.

Using this method, cells from one mouse could be used to test 1000 drug compounds to treat liver disease, and reduce animal use by up to 50,000.

2013

Social amoebae for epilepsy research
 

A multi-chamber device to study neural degeneration
 

Testing chemicals for endocrine disrpution using fewer fish
 

A bioreactor to predict the efficacy of antifungal therapies
 

Using facial expressions of pain in animals
 


 

Latest podcast

NC3Rs 3Rs Prize - Taking inspiration from human orthopaedics to improve research with monkeys
 

2014

NC3Rs 3Rs Prize - Immune cells grown in lab could significantly reduce animal use in research
 

2013

The virtual tumour and other posters from the SoB/NC3Rs joint sympoisum
 

Searching for the cure to epilepsy: from slime mould to coconuts