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NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research

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30 results

Guidelines on implementing the 3Rs in both field and captive studies.

Two wild frogs

Reducing and refining acute toxicity tests in the pharmaceutical and chemicals industries.

A white mouse on a technician's gloved hands

Providing an evidence base to refine and reduce the use of vertebrates in (regulatory) ecotoxicology studies

A group of young rainbow trout

Using exposure science to refine and reduce animal use, and support the uptake of new approach methodologies

A lister hooded rat (black head white body) seen in a standard rat housing cage. The rat is standing on a plastic box and is looking out of the open cage lid.

Techniques for blood sampling in laboratory animal species to ensure the most appropriate technique is chosen.

Five needles with empty syringes on a pale blue background

Paper clarifies that the forced swim test is not a regulatory requirement for the development of new antidepressants (NC3Rs & MHRA project).

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Amanda Novak (Edinburgh) presents advice on good surgical technique and refinements to incorporate into rodent stereotactic surgery procedures.

Webinar title slide: Refining rodent stereotactic surgeries

Guidelines for establishing, implementing and refining humane endpoints.

A white mouse on a technician's gloved hands

Archiving can provide a back-up to production colonies, minimise genetic drift, reduce the need for tick-over colonies and preserve valuable models.

A white sperm and egg icon on a blue background

Learn more about why the single use of needles should be standard practice and how to implement this in your facility.

A rat being injected with a hypodermic needle