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NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research

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154 results

Using exposure science to refine and reduce animal use, and support the uptake of new approach methodologies

A lister hooded rat (black head white body) seen in a standard rat housing cage. The rat is standing on a plastic box and is looking out of the open cage lid.

Guiding strategy and encouraging the adoption of microsampling techniques within any research or safety study.

A brown and white rat in the gloved hands of an animal technician.

Guidance on reducing or refining animal use for studies with cardiovascular, central nervous system and respiratory functional measurements.

A beagle at an indoor play area

Quarterly e-newsletter to keep the scientific community updated on news from the NC3Rs Toxicology and Regulatory Sciences programme.

A white icon of an envelope on a purple background.

Details of the Mouse Grimace Scale, including a poster for display in laboratory rooms and corridors.

Screenshot of the top third of the mouse grimace scale poster showing the orbital tightening facial action units

Details of the Rat Grimace Scale, including a poster for display in laboratory rooms and corridors.

Screenshot of the top third of the rat grimace scale poster showing the orbital tightening facial action units

Guidance on best practices in confirming, archiving and maintaining strains, as well as re-establishing colonies after a pause.

A litter of black mice with an adult mouse, nesting in the corner of their home cage

An introduction to systematic reviews, a powerful method used to assess accumulating evidence related to a specific research question.

A stack of papers
External link

Reporting guidelines for animal experiments, and additional resources to support their use.

a physical copy of the ARRIVE guidelines

A dedicated, open access portal for our Grant holders to showcase their 3Rs research.

F1000 and NC3Rs logo on orange background