Using exposure science to refine and reduce animal use, and support the uptake of new approach methodologies
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Guiding strategy and encouraging the adoption of microsampling techniques within any research or safety study.
Supporting the uptake of new approach methodologies to reduce reliance on traditional animal toxicity tests
Guidance on reducing or refining animal use for studies with cardiovascular, central nervous system and respiratory functional measurements.
Projects providing guidance to reduce animal use or refine procedures within toxicology studies.
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10 years of CRACK IT webinar: The Human In Vitro Gene Therapy Genotoxicity Testing service.
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A webinar exploring how environmental monitoring can replace the use of sentinel animals for monitoring mouse colonies for the presence of pathogens.
A webinar series from a cross-European group of 3Rs centres exploring the challenges and opportunities of replacing BMEs.
Quarterly e-newsletter to keep the scientific community updated on news from the NC3Rs Toxicology and Regulatory Sciences programme.
Information to help refine the housing and husbandry of the laboratory hamster.
External link
The evidence supporting the use of tunnel and cup handling to improve animal welfare and scientific outcomes (presented at AALAS 2021).
Details of the Mouse Grimace Scale, including a poster for display in laboratory rooms and corridors.
Information to help refine the housing and husbandry of the laboratory mouse.
Details of the Rat Grimace Scale, including a poster for display in laboratory rooms and corridors.
Information and support for the adoption of alternative approaches and technologies.
External link
10 years of CRACK IT webinar: An IVF micro microfluidic device for non-surgical embryo transfer to generate transgenic mice.
Information to help refine the housing and husbandry of the laboratory dog.
Guidance on best practices in confirming, archiving and maintaining strains, as well as re-establishing colonies after a pause.
External link
An online tool to guide researchers through designing experiments involving the use of animals.
An introduction to systematic reviews, a powerful method used to assess accumulating evidence related to a specific research question.
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Reporting guidelines for animal experiments, and additional resources to support their use.
A dedicated, open access portal for our Grant holders to showcase their 3Rs research.
Reasons for conducting a pilot study and what you can do with the results.
Tips to avoid common pitfalls when describing your experimental design and methodology in a funding proposal.
