Challenge 30 RaTS A handheld device for objective monitoring of rheumatoid arthritis (RA) progression in awake rodents.
Challenge 29 ImmuLiver An immunologically-competent in vitro model of the human liver for the assessment of Yellow Fever (YF) vaccine attenuation.
Challenge 28 RespiraTox An in silico QSAR-based tool that reliably predicts the human respiratory irritancy potential of chemicals.
Challenge 27 DoCE Improved tools to better quantify and control the exposure of chemicals over a wide range of in vitro assay systems.
Challenge 26 DARTpaths Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects.
Challenge 25 Maximise An in silico model to classify agrochemical mixtures to fulfil acute GHS Classification and Labelling requirements for acute oral toxicity, skin and eye irritation.
Challenge 24 EASE An approach that improves the implantation rates of early stage embryos when combined with extended in vitro culture and non-surgical embryo transfer techniques in the generation of transgenic mice.
Challenge 23 Retinal 3D An in vitro 3D retinal cell model which is physiologically-competent and predictive of human physiology for use in the development of new ophthalmology treatments.
Challenge 22 Osteo-chip A human cell based in vitro model to recapitulate the human osteoarthritic joint for research and drug development in OA.
Challenge 21 InMutaGene A suite of in vitro / in silico assays that can be used to improve risk assessment for gene therapy products.
Challenge 20 Metaboderm A model to assess the extent to which skin metabolism determines xenobiotic availability in human skin.
Challenge 19 QSARs Mix Using existing toxicological data repositories to develop in silico tools to predict toxicological endpoints for substances in order to waive in vivo studies.
Challenge 18 Targeting off targets The development of novel approaches to address the potential human safety issues arising from chemicals interacting with ‘off-target’ receptors.
Challenge 17 Neuratect A physiologically-relevant human stem cell-based model to assess neurotoxicity and seizure liability.
Challenge 16 VIDR A virtual platform that models infection and the host response to pathogen assault for basic research and enhances new target development in infectious diseases.