- Please tick if tunnel handling or cupping are routinely used in your facility
- Please tick if you are a NTCO or trainer
- Please tick if you attended the 2017 Mouse Handling Workshop
Take this opportunity to get the support you need for best practice in mouse handling.
Research at universities in Liverpool, Newcastle, Cincinnati and Tokyo has shown that picking up mice by the tail induces aversion and high anxiety in the animals, whereas use of a handling tunnel or cupped hands avoids or reduces these negative responses1-6. Non-aversive handling also leads to more robust and reliable responses in behavioural and pharmacological tests, benefiting the science the animals are used for4-6.
The NC3Rs is supporting the scientific community to implement the refined handling methods via a video tutorial, posters, FAQs and other resources, all of which can be found on our 'How to pick up a mouse' hub. Some establishments no longer pick up mice by the tail, and momentum for change is growing at many others. Concerns from staff about changing handling methods most often stem from misunderstandings about how and when to implement the refined techniques.
We are hosting a free mouse handling workshop on Monday 26 November 2018 to further support establishments to adopt the refined techniques. This event is a repeat of our September 2017 workshop. It is open to all7 but trainers, NTCOs and other named persons are particularly encouraged to attend. Come to the workshop to:
The provisional agenda is now available.
The deadline for registration is 12 November 2018.
1Hurst JL, West RS (2010) Taming anxiety in laboratory mice. Nature Methods 7:825-826.
2Gouveia K, Hurst JL (2013) Reducing mouse anxiety during handling: Effect of experience with handling tunnels. PLoS ONE 8(6): e66401.
3Gouveia K, Hurst JL (2017) Optimising reliability of mouse performance in behavioural testing: the major role of non-aversive handling. Scientific Reports 7: 44999.
4Ghosal S et al. (2015) Mouse handling limits the impact of stress on metabolic endpoints. Physiology and Behaviour 150:31-37.
5Clarkson JM, Dwyer DM, Flecknell PA, Leach MC, Rowe et al (2017) Handling method alters the hedonic value of reward in laboratory mice. Scientific Reports 8: 2448.
6Nakamura Y, Suzuki K (2018) Tunnel use facilitates handling of ICR mice and decreases experimental variation. J Vet Med Sci 80(6): 886-892.
7The policy on attendance at NC3Rs events applies.