Skip to main content

Welcome to the new NC3Rs site, find out more about the changes and improvements we have made.

NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research

NC3Rs Webinar - Launch of 2021 CRACK IT Challenge 41: Innovative Safety Assessment of Fish adverse Effects (SAFE)

Registration Details

Event date and time


Over the past ten years, CRACK IT Challenges has spearheaded the development of innovative 3Rs technologies through a growing portfolio of products and services that deliver improved scientific data, more predictive models and reduce the reliance on animals. From non-invasive home cage monitoring and human relevant stem cell models to in silico platforms, approaches developed through CRACK IT are delivering real world scientific and 3Rs benefits across multiple industry sectors and in basic research.

CRACK IT products can be found on our Innovation Platform and case studies highlighting some of our successes are showcased in our 10 years of CRACK IT: Webinar series.

2021 Challenge launch

This webinar will launch the 2021 CRACK IT Challenge 41: SAFE - Innovative Safety Assessment of Fish adverse Effects.

Environmental risk assessment evaluates the likelihood that the environment may be impacted by exposure to one or more chemical stressors and is assessed across three trophic levels, with fish used as the vertebrate species when in vivo testing is required. This Challenge aims to develop a suite of innovative, scalable bioassays for key adverse outcome pathways to replace in vivo fish studies in chemical safety screening and regulatory environmental risk assessment.

This is a two Phase Challenge sponsored by Bayer AG, AstraZeneca and Unilever and co-funded by DEFRA and the Environment Agency.  Further information about this Challenge can be found on the NC3Rs Innovation Platform.

This webinar will give you an opportunity to learn more about the competition, ask the Sponsors questions and find out how to submit a competitive application.

Register via Zoom