Workshop: Application of non-animal approaches for decision-making in chemical safety assessment

  • NC3Rs
Monday 10 December 2018 to Tuesday 11 December 2018
Central London

In collaboration with Unilever, the NC3Rs is jointly hosting a two-day workshop in central London on 10-11 December 2018. 

Non-animal approaches (i.e. in vitro and in silico) can provide useful information to inform decision-making for chemical safety assessment in product development programmes.  However, there can be a lack of confidence in these methods, particularly within a regulatory setting.  Methods that focus on mechanistic approaches and incorporation of exposure science can make non-animal approaches more useful for decision-making purposes, and can therefore support a reduction in the current reliance on data from animal tests.

The meeting will bring together academic and industry researchers across multiple disciplines to share their knowledge and experiences in applying non-animal (i.e. in vitro and in silico) methods for decision-making for efficacy and safety assessment.  The workshop will be attended by expert scientists from academia, government and regulatory agencies and the (agro)chemicals, consumer products, and pharmaceutical industries.

The key objectives of the workshop are to:

  • Showcase how non-animal approaches (i.e. in vitro and in silico) are currently being used to enable and improve decision-making for chemical safety assessment, including the use of AOPs/mechanistic approaches and incorporation of exposure science.
  • Increase awareness and acceptance of non-animal approaches to accelerate their uptake to support decision-making, particularly in a regulatory setting.
  • Identify scientific gaps that if addressed could have a significant impact on the application and uptake of non-animal approaches.
  • Encourage collaboration between sectors, to share knowledge and ‘lessons learned’ to maximise the impact of non-animal approaches and to improve safety and efficacy decision-making.


The workshop will be chaired by Professor Ian Kimber OBE, Professor of Toxicology at the University of Manchester. Discussions will focus on what is needed to give ‘comfort’ and confidence in these new approaches to make decisions for safety assessment.

Confirmed speakers include:

  • Dr Paul Andrews, SimOmics, UK
  • Dr Warren Casey, NICEATM, USA
  • Dr Rebecca Clewell, 21st Century Tox Consulting, USA
  • Dr Joshua Harrill, U.S. Environmental Protection Agency, USA
  • Dr Delyan Ivanov, AstraZeneca, UK
  • Dr Hans Ketelslegers, Concawe, Belgium
  • Dr Robert Landsiedel, BASF, Germany
  • Dr Donna Macmillan, Lhasa Limited, UK
  • Dr Luigi Margiotta-Casaluci, Brunel University, UK
  • Dr Tina Mehta, Adama, UK
  • Professor Aldert Piersma, RIVM, The Netherlands
  • Dr Tomasz Sobanski, ECHA, Finland
  • Professor Mathieu Vinken, Vrije Universiteit Brussel, Belgium
  • Dr Carl Westmoreland, Unilever, UK
  • Professor Maurice Whelan, JRC, Italy
  • Professor Martin Wilks, Swiss Centre for Applied Human Toxicology, Switzerland


Delegates are encouraged to submit poster abstracts on a topic relevant to the theme of the meeting and highlighting the potential 3Rs benefits. To present a poster, please complete the abstract submission form and submit by 16 November 2018. We will let you know if you have been successful by 23 November 2018.


Attendance is free, but registration is essential. The closing date for registration is 26 November 2018.

You will need an NC3Rs website account to register. Please use your institutional email address when registering.

Event status

Registration now closed