Impacts from our 2013 Research Review

We have positioned the UK at the forefront of 3Rs efforts globally. Funding cutting-edge research and world class scientists has been key to this. Here we showcase examples from our 2013 Research Review to illustrate the breadth of the science we support and the benefits delivered.

High impact projects range from new discoveries in epilepsy and cancer research, changes to international regulations for testing endocrine disrupting chemicals, through to addressing major challenges faced by the pharmaceutical industry.

3D tumour models to reduce the use of animals in early preclinical cancer studies.
Modelling colorectal cancer in Drosophila to minimise the use of mice.
Using an in vitro model of the human alveolus to study antifungal agents.
A new sampling protocol for vaccine and immunology studies in fish.
Using Dictyostelium to screen and identify potential anti-epileptic drugs.
A multi-chambered in vitro system for the study and manipulation of axon degeneration.
A novel telemetry device to eliminate the repeated infections associated with current methods of EMG recording in monkeys.
Assessing pain using facial expressions in laboratory mice, rats, rabbits and macaques.
Assessing the humaneness of gaseous euthanasia techniques for laboratory rodents.
A new human cell genotoxicity assay to reduce the use of animals in drug development.
Reducing the number of fish used for testing the effects of chemicals on sexual development.
New cell-based assays for the detection of botunlinum toxins.
New mouse model of multiple sclerosis focusing on the optic nerve rather than severe motor impairments.
An in vitro model which mimics key aspects of spinal cord injury.
Avoiding the use of animals to study genetic and environmental influences on asthma.
Using embryonic cell lines to investigate kidney development without the use of mice.
Avoiding severe endpoints and reducing the number of animals used.
Replacing the use of primary motor neurones with induced pluripotent stem cells.
Improving and validating a pseudoislet model as an alternative to the use of primary islets in diabetes research.
Minimising the likelihood of infections in monkeys with head implants.
Replacing the use of mouse xenografts for studies of cancer stem cells.
New in vitro assays which are more sensitive and accurate than the previously used mouse tests.
A transgenic mouse model which avoids the need for repeat injections and widespread inflammation in the animals.
An ex vivo three-dimensional model of the lower jaw.
Using bioluminescent imaging to refine and reduce animal studies of bacterial infection.
A new model with less suffering which better mimics the human disease.