Mathematical modelling in toxicology

This call is closed


This call aims to fund research proposals, to address genuine mathematical challenges which develop new, or apply existing mathematical models to toxicology research and safety testing with the aim of:

  • Providing more scientifically relevant information for human and environmental safety assessment
  • Reducing reliance on animals and/or improving animal welfare

This call is co-funded by the EPSRC

Who can apply? | How to apply | Assessment procedure | Assessment panel | Resources and awards

 Who can apply?

Establishment eligibility

Individual eligibility

Any UK research establishment including:

  • Higher Education Institutions (HEIs)
  • Independent Research Organisations (IROs)
  • Research Council (RC) Institutes
  • Hospital/NHS Trusts
  • Charity Laboratories
  • Industry

Applicants should be UK-based researchers who can demonstrate that they:

  • Will direct the proposed research
  • Will be actively engaged in accomplishing the project’s aims
  • Hold a graduate degree – the minimum formal qualification required. However, it would normally be expected that an applicant has been awarded a PhD. Applications involving less experienced researchers should be made in collaboration with a more senior colleague.

In addition to the points above the research team must include both mathematicians and toxicologists. If one discipline is only represented as a collaborator, it must be demonstrated that there will be a significant level of collaboration.

Overseas researchers

Overseas researchers cannot be principal applicants but can be included as collaborators. Overseas co-applicant status can be obtained in exceptional circumstances and at the discretion of the NC3Rs; approval should be sought before applying.


The NC3Rs does not allow resubmission of previously unsuccessful proposals, unless explicitly invited by the Panel. Proposals previously declined by the NC3Rs will not be considered by another Research Council or funder within 12 months (from the date of submission to the original Research Council) unless substantially revised. More information can be found in the NC3Rs Applicant and Grant Holder Handbook.

Please note: The same or similar application cannot be considered by any other Research Council, the Health Departments or any other research funder at the same time.

Back to the top

How to apply

This call is now closed. For information on future Strategic Award calls please sign up to the NC3Rs Newsletter for updates.

Back to the top

Assessment procedure

Applications are evaluated by international peer reviewers and assessed by the NC3Rs Strategic Award Panel.

The following criteria will be taken into consideration when making funding decisions:

  • Relevance to the strategic call
  • Potential impact on the 3Rs
  • Quality of the science
  • Current or future importance of the techniques to medical, biological or veterinary research
  • Strategy for promoting the proposed research to the scientific community
  • Expertise and track record of the team
  • Relevance to the NC3Rs strategy
  • Value for money

Back to the top

Assessment panel

The following panel considered applications submitted to this competition. 

Member Name  Institution

Professor Ian Kimber (Chair)

University of Manchester

Dr Fordyce Davidson 

University of Dundee

Dr Matthias Heil 

University of Manchester

Dr Kevin Painter 

Heriot-Watt University

Dr John Pinney 

Imperial College

Dr David Smith 

University of Birmingham

Dr Heather Wallace 

University of Aberdeen

Dr Carl Westmoreland 


Back to the top

Resources and awards

A total budget of up to £750k was available for projects of up to three years duration. 

Four awards were made in October 2012

Dr Gary Mirams
(University of Oxford)

Prediction of human cardiotoxic QT prolongation using in-vitro multiple ion channel data and mathematical models of cardiac myocytes

Dr Jonathan Pitchford   
(University of York)

Imprecision and importance: Probabilistic graphical models in toxicology
Dr John Gosling  
(University of Leeds)
Uncertainty and confidence in applying mathematical models and in vitro data in toxicological safety assessments
Dr Michael Chappell     
(University of Warwick)
Structural Identifiability and Indistinguishability Analysis as Tools for Quantitative and Systems Pharmacology to Support the 3Rs

Back to the top