NC3Rs e-newsletter - April 2016


The NC3Rs supports the Pint of Science festival

We are proud to announce our ongoing partnership with the international Pint of Science festival, taking place from 23 to 25 May in pubs around the UK.

This year we have sponsored three events, in London, Edinburgh and Southampton, which will discuss a range of NC3Rs-funded projects.

Tickets to each event are available for £4.



Guidance on social housing during telemetry studies

An NC3Rs working group created to identify the opportunities and barriers for adopting best practice in the social housing of non-rodents (within pharmacology and toxicology studies) has recently published its findings.

The group, which was led by the NC3Rs in collaboration with the Safety Pharmacology Society, developed a survey focusing on current practices in telemetry and produced recommendations to improve animal welfare during the studies. The paper entitled ‘Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies’ is available in the Journal of Pharmacological and Toxicological Methods.



Call for nominations: the IQ Consortium/AAALAC International 3Rs Awards

The Global 3Rs Awards programme run by the IQ Consortium and AAALAC recognises significant and innovative contributions towards the 3Rs by researchers, in academia or industry, from across the world.

The competition is currently accepting nominations, which should be based on a primary research paper that advances any of the Rs, published in a peer-reviewed journal in the last three years.

The deadline to submit a nomination is Wednesday 15 June 2016 at 4pm EDT.



David Sainsbury Fellowship: call for outlines

Our David Sainsbury Fellowships support talented, 3Rs-minded, early-career scientists with their transition to an independent career.

Applications are accepted from any area of medical, biological or veterinary research. The scheme offers fellows an award which covers their salary (as agreed with their host institution) and up to £30k for other directly incurred research costs per annum for three years.

The deadline for the submission of outlines is Tuesday 26 April 2016 at 4pm BST.



Increasing the relevance of in vitro hepatocyte models for liver toxicity testing

A recently published paper has shown that improving the physiological relevance of in vitro hepatocyte-like cell cultures can, by introducing shear stress, increase their utility as models for liver toxicity testing.

The research is the result of collaboration between the University of Edinburgh and biotechnology company Kirkstall Ltd, and was supported through funding from the NC3Rs CRACK IT Solutions partnering programme.



CRACK IT Solution: TruLarv™ Galleria mellonella: a model host for infection studies, toxicity testing and drug development

Are you interested in the application of invertebrate models as early screens for efficacy and toxicity testing of drugs and other chemicals? Biosystems Technologies Ltd. have developed research grade G. mellonella larvae and are seeking partners to help validate their utility in drug and chemical development pipelines.



Recent advances in alternative approaches for chemical safety assessment and regulatory perspectives

Thursday 19 May: LONDON
The NC3Rs and the UK’s Interdepartmental Group on Health Risks from Chemicals (IGHRC) are co-hosting a one-day workshop aimed at UK regulatory risk assessors and government agency toxicologists.

The workshop will include case studies on non-animal and alternative approaches to risk assessment with regulatory and industry perspectives, a panel discussion on regulatory challenges and a group discussion considering the question: “How can the UK science base influence the paradigm shift towards more predictive, animal-free safety testing?”

Attendance is free, but registration is essential. The closing date for registration is Thursday 12 May 2016.



Call for speakers for LASA winter meeting

Tuesday 22 November - Thursday 24 November: SOUTH OF ENGLAND
The Laboratory Animal Science Association is currently inviting submissions for presentations on any aspect of the 3Rs for its winter meeting.

A title and abstract must be sent no later than Monday 6 June 2016.


Find all of our most recent posts, along with our back catalogue here.


Experimental design in the limelight

We have launched a new series of monthly blog posts written by our Chief Executive, Dr Vicky Robinson.

In her first blog, Vicky covers the important and topical issue of experimental design, focusing on current challenges faced by researchers and how the NC3Rs strategy aims to tackle these.



The NC3Rs 3Rs Prize was awarded to two researchers this year (2015 award). The following two blog posts describe the work which we recognised as being outstanding 3Rs research.


Mini-brains show great potential to replace animals in studying neurological disease

Dr Madeline Lancaster and her colleagues have, for the first time, created cerebral organoids, reflecting the complex structure of the developing human brain using in vitro methods. This blog describes the science behind her breakthrough research and its potential to reduce the use of animal models in neurological studies.



Improving the welfare of laboratory dogs

Dr Laura Hall and her colleagues were recognised for their work which aims to improve the welfare of laboratory dogs by refining the technique of oral dosing to reduce stress.