NC3Rs e-newsletter - December 2015


Launch of Rabbit Grimace Scale posters

We are now offering A3 Rabbit Grimace Scale posters free of charge for display in animal facilities.

This resource is the result of research by Dr Matthew Leach, Newcastle University, who was awarded NC3Rs funding to validate the use of facial expressions for assessing post-procedural pain in a range of laboratory animal species, including the rabbit.

We also offer Mouse and Rat Grimace Scale posters. Please email to order.



NC3Rs-funded research in amoeba helps understand treatment of drug-resistant epilepsy

A paper by NC3Rs grantholder Professor Robin Williams has been published in Brain, identifying a specific fatty acid to have potent anti-epileptic effects.

Researchers from Royal Holloway London pinpointed decanoic acid as an efficient blocker of a key excitatory neurotransmitter receptor involved in seizure activity in the brain. To do that, they initially analysed many fats in a simple system that avoided the use of animals in experiments.

This study builds on previous research funded by the NC3Rs, which successfully used amoeba in an initial screen to identify compounds efficient in seizure treatment.



Human cell and regenerative medicine technologies report published

A report exploring the application of cutting-edge cell and tissue-based technologies in drug discovery has been published today, covering four priority areas that were showcased in a workshop co-hosted by the NC3Rs earlier this year.

The report emphasises the continued need for investment and long-term partnerships so that technology to support the 3Rs can be developed.



InVivoStat v3 release

An updated version of InVivoStat, the free statistical analysis package designed for animal researchers, has just been released.

The package can be used in conjunction with the NC3Rs Experimental Design Assistant (EDA) so that researchers can design experiments in the EDA and perform the statistical analyses using InVivoStat.

The EDA and InVivoStat help researchers with the design and analysis of animal experiments, ensuring that studies robustly answer the question they are intended to, using the minimum number of animals.



Opportunities for archiving and sharing mouse lines at the Mary Lyon Centre

The Mary Lyon Centre at MRC Harwell offers a non-profit archive that supports scientists worldwide through the archiving and distribution of mouse lines. The archive acts as the UK archiving node for the European Mouse Mutant Archive (EMMA).



Updated funding page resources

We have recently updated our funding page to include new resources for applicants and current grant holders.

Professor Ian Kimber, NC3Rs Project Grants Panel Chair, offers a panel perspective in a new five-minute video discussing his experience of sitting on an NC3Rs Panel and what he expects to see in a strong grant application.

There is also a new presentation available to download, highlighting top tips and providing advice from our funding team to help applicants determine whether their project is likely to be competitive and also what factors they need to consider when preparing their application.



Infrastructure for Impact funding scheme closes soon

We are seeking outline applications for the next round of our Infrastructure for Impact funding scheme. The scheme supports infrastructure, networks, data sharing and other resources which help to underpin 3Rs research.

The deadline for outline applications is 4pm (GMT), 6 January 2016.



Project Grant scheme open for proposal submission

We are currently accepting outlines for research projects to develop new 3Rs approaches and technologies in any area of medical, biological or veterinary research.

The deadline for outline submission via Je-S is 4pm (GMT) 13 January 2016.


Find all of our most recent posts, along with our back catalogue here.


Sharing refinements of chronic implants

Dr Daniel Adams, University of California San Francisco, describes the latest resource from the NC3Rs aimed at refining neuroscience experiments using non-human primates: the Chronic Implants Wiki.