NC3Rs e-newsletter - July 2018


Announcing our 2019 highlight notice


To encourage funding applications relating to areas of strategic importance to the NC3Rs, we issue regular highlight notices that apply across our funding schemes. Our 2019 highlight notice will support the development or transfer of innovative applications of non-mammalian organisms by facilitating new partnerships between rodent and non‑mammalian model organism users.



2019 highlight notice launch event


4 September 2018 (Central London)


We are launching our 2019 highlight notice with a workshop that will bring together rodent and non-mammalian model organism users. The workshop will feature talks, flash presentations and networking opportunities, as well as information about the highlight notice and applying for an NC3Rs grant.


Attendance is free, but registration is essential. The deadline for registration is 4pm on 21 August.



Improving peer review of in vivo research proposals: workshop presentation videos now online


We recently hosted a workshop on experimental design for funding panel members of the NC3Rs, BBSRC, CRUK, MRC and Wellcome Trust. Videos of the workshop presentations are now available to watch online. As well as supporting funding panel members to assess in vivo research proposals, the videos can help applicants to ensure their proposals provide quality information on experimental design.




Listen to the latest episode of “3 Minute 3Rs”


“3 Minute 3Rs” is the podcast that gives you the lowdown on the latest 3Rs research every month in just a few short minutes. This month’s edition tackles papers on refining mouse anaesthesia, transplanting human stem cells into zebrafish, and validating genome-edited mouse lines.




New NC3Rs Regional Programme Managers appointed


This month we have welcomed two new Regional Programme Managers to our team. Dr Chris Barkus is based at the University of Oxford, while Dr Jessica Eddy works across the universities of Bath, Bristol, Cardiff and Exeter (the GW4 Alliance). Please get in contact with them for support in implementing the 3Rs within these institutions.



2018 CRACK IT Challenges announced


This year’s CRACK IT Challenges competition consists of three Challenges identified jointly by the NC3Rs and Sponsors:

  • Challenge 29: ImmuLiver – An immunologically-competent liver model to assess attenuation of yellow fever vaccines.

  • Challenge 30: RaTSRaman Transmission Spectroscopy for objective monitoring of rheumatoid arthritis progression in rodent models.

  • Challenge 31: MoshersMouse Smart Hoppers.

This year the competition is funded by the NC3Rs, with co‑funding provided by EPSRC (RaTS) and in-kind contributions from the Sponsors.



2018 CRACK IT Challenges launch event


6 September 2018 (Central London)


Join us to learn more about this year’s Challenges, meet the Sponsors, network with potential collaborators, and find out what makes a good application.


Attendance is free, but registration is essential. The deadline for registration is 31 August.



New CRACK IT Solution: Ex vivo corneal model to assess drug delivery


Researchers at the University of Birmingham have developed a low cost, ex vivo porcine corneal model to rapidly assess ocular drug delivery. The assay, which uses surplus tissue from the food industry, has been shown to be more predictive of human drug delivery outcomes than in vivo rabbit and rodent models.

Industrial collaborators are sought to further validate the assay by providing different classes of ocular drugs and drug penetration data.




Apply now for our 2018 Training Fellowship scheme


Our Training Fellowship scheme supports promising early career researchers, focusing on developing new skills and gaining a breadth of research experience. If you have less than three years’ post-doctoral experience, you can apply for two years of funding through the scheme.


Applications must be received by 4pm on 12 September.




The NC3Rs at the 2018 AALAS National Meeting


28 October – 1 November 2018 (Baltimore, USA)


NC3Rs staff members will be attending this year's AALAS National Meeting. We will have a booth (#2010) in the trade exhibition and will be participating in this year’s Technician’s Fun Fair. We will also be delivering three talks on our activities, as well as co-sponsoring a workshop on training monkeys to cooperate with restraint using positive reinforcement techniques.




3Rs speakers wanted for the 2018 LASA Annual Conference


The LASA 3Rs section conveners are inviting submissions for presentations on any aspect of the 3Rs to be delivered at the 2018 LASA Annual Conference. Early career researchers are particularly encouraged to apply. Speakers will receive free registration, as well as travel expenses and overnight accommodation if required.


Please send submissions to Patricia Pimlott at by 31 July.