NC3Rs e-newsletter - July 2019


Join the NC3Rs team and support our work on research animal welfare


We are recruiting maternity cover for our Animal Welfare Programme Manager role, overseeing our programme of activities to improve the welfare of research animals. If you have a passion for animal welfare, a PhD in a biological science and experience of reviewing research proposals or project licence applications, this could be the role for you.


The closing date for applications is Thursday 1 August.




Burrow into our new citizen science project


We have collaborated with MRC Harwell to create a new citizen science project based on the Rodent Little Brother CRACK IT Challenge. The project, hosted by Zooniverse, will give anyone interested in improving mouse welfare the chance to get involved in research by watching videos of mice filmed in their home cages and labelling their behaviour. This will help teach an algorithm how to recognise different behaviours, enabling data to be analysed automatically.




Could you be the next Chair of the NC3Rs Board?


We are recruiting a new Chair to lead the NC3Rs Board from January 2020. This is an opportunity to help shape our strategy and promote the UK as a world leader in 3Rs research. Candidates for this role should have leadership experience and a distinguished international research track record, as well as a vision of priorities and opportunities for the 3Rs across the biosciences.


The deadline to apply is 4pm on Tuesday 27 August.




Share your thoughts on ICH S7


Do you design or perform ICH S7 safety pharmacology studies, or make decisions based on the resulting data? If so, we want to hear from you.


We have teamed up with the Safety Pharmacology Society to produce a survey on the studies outlined within ICH S7 guidance for first-in-human testing of new pharmaceutical products. The survey will take around 10 minutes to complete and will remain open until Friday 30 August.




Development of a new automated monitoring tool for zebrafish


A new paper published in Scientific Reports describes the Fish Behaviour Index, an automated tool to monitor zebrafish behaviour and assess their welfare. The tool was developed by NC3Rs grant holder Dr Lynne Sneddon and colleagues at the University of Liverpool. It uses a camera and tracking software to record the 3D trajectories of singly-housed fish and assess how they change in response to laboratory procedures.




Complete this short survey on assessing the welfare of amphibians


NC3Rs-funded PhD student Lola Brookes is conducting a survey on indicators of pain and suffering in amphibians, focusing on which indicators are currently being used and which are potentially the most useful for improving their welfare. The survey will take around 20 minutes to complete – if you work directly with any amphibian species, we encourage you to take part and contribute to this research.




2019 CRACK IT Challenges announced


This year’s CRACK IT Challenges competition consists of three Challenges identified jointly by the NC3Rs and Sponsors:

This year the competition is funded by the NC3Rs with in-kind contributions from the Sponsors.


We are hosting a meeting to launch the competition in central London on Wednesday 11 September, providing invaluable access to potential new partners and to the Challenge Sponsors. Attendance is free but registration is essential. Register for the launch event via the NC3Rs Innovation Platform before Wednesday 4 September.




New Solution: In ovo model for immuno-oncology screening


Inovotion has developed a model that uses embryonated chicken eggs with a complete immune system to test the efficacy and toxicity of anticancer drug candidates. This approach could reduce the use of humanised mouse models in preclinical testing. Inovotion is now seeking partners from academia and industry to provide diverse immuno-oncology compounds (with preclinical data available) to test in the model.




2019 CRACK IT Reception


Wednesday 11 September (central London)


This evening reception will mark the publication of a review of our CRACK IT open innovation programme, highlighting new 3Rs technologies and products delivered, as well as the scientists and engineers behind them. Come along if you want to hear more about our CRACK IT programme and how you can get involved.


The deadline to register for this event is Monday 2 September.




2019 NC3Rs/IAT Animal Technicians’ Symposium


Wednesday 2 October (central London)


If you are a junior technician, our upcoming symposium will give you the chance to learn more about the latest advances in laboratory animal welfare and how to put the 3Rs into practice. We’re currently seeking poster presentations on 3Rs topics – the best poster will win £100, so why not take this opportunity to share your ideas?


Attendance is free, but registration is essential. The deadline to register is Friday 13 September. Bursaries of up to £100 are available to help with travel expenses.




2019 Primate Welfare Meeting


Friday 8 November (central London)


Registration is now open for our annual Primate Welfare Meeting. This event offers attendees a unique opportunity to share best practice in the use and care of non-human primates internationally. This year’s meeting will have a workshop format and focus on harmonising welfare indicators for macaques and marmosets.


We are currently accepting abstracts for poster presentations, which should be submitted by 5pm on Friday 30 August.




3Rs speakers wanted for the 2019 LASA Annual Conference


LASA is inviting submissions for presentations on any aspect of the 3Rs for the 2019 LASA Annual Conference. Early career researchers are particularly encouraged to apply. Speakers will receive free registration, as well as travel expenses and overnight accommodation if required.


Please send submissions to Patricia Pimlott at by Wednesday 31 July.




Funding available from the Biomedical Research Education Trust


The Biomedical Research Trust is a charity that funds work to improve the care, use and replacement of animals in scientific research. They are currently inviting funding proposals for projects that promote the use and development of 3Rs methods. Grants are usually up to £5,000, but proposals for bigger projects may be considered.


To find out more, please email