NC3Rs e-newsletter - June 2015


Design award won by medical technology with 3Rs applications

The winner of the 2015 London Design Museum's Design of the Year award has been announced, awarded to a team from Harvard who are developing organs-on-chips.

The team, led by Professor Don Ingber and Dr Dan Dongeun Huh, are well known to the NC3Rs, having won our 3Rs prize in 2012 for their innovative technology.



Board member vacancies
Deadline: 31 July 2015, 4pm

We are inviting applications from talented senior scientists to join the NC3Rs Board from January 2016.

The person specification and application form can be found on our Board member vacancies webpage.



F0-ols Rush In

In the latest piece in our series on genetically-altered mice, Sara Wells from MRC Harwell focuses on how to ensure data is reproducible using the relatively new CRISPR/Cas9 technology.


NC3Rs/IAT Animal Technicians' Symposium
16 September 2015: LONDON

Register now for our one day symposium with the Institute of Animal Technology. Speakers will cover welfare assessment, refinements to procedures, and the role of named persons under the ASPA. Attendance carries 5 IAT CPD points. Ten travel bursaries are available and there is a £400 prize for the best poster (deadline for bursary applications and poster abstract submissions is 31 July).



3Rs alternatives & consistency testing in vaccine lot release testing
16-18 September: THE NETHERLANDS 

The NC3Rs is co-sponsoring a conference on the consistency approach for the batch release of vaccines. Around 10% of animal use is for vaccine batch testing. The consistency approach involves developing manufacturing quality control processes to avoid the use of animals altogether. The conference will focus on the latest scientific advances and regulatory issues to support the adoption of the consistency approach.



2015 IVTS Annual Meeting
10-11 November: BIRMINGHAM

Session themes include in vitro approaches to inhalation toxicology, neurotoxicology, hepatotoxicology, reproductive and developmental toxicology.

There are also poster sessions and early career speaking slots.



Adverse Outcome Pathways can drive non-animal approaches for safety assessment

A new article from the NC3Rs in collaboration with academic experts explores how the development and application of Adverse Outcome Pathways (AOPs) could benefit the science and practice of chemical safety assessment, with a particular focus on how their use could reduce reliance on traditional animal toxicity tests. The article includes discussion of the key areas where current and future initiatives should be focused to enable the translation of AOPs into routine chemical safety assessment, and lasting 3Rs benefits.

Testing chemical safety: what is needed to ensure the widespread application of non-animal approaches?

An essay from the NC3Rs has been published recently in PLoS Biology and discusses the incentives, hurdles, and on-going initiatives towards a reduced reliance on traditional animal toxicity tests in the safety assessment of chemicals.