NC3Rs e-newsletter - June 2016


Vacancies at the NC3Rs

Do you have a demonstrable commitment to the 3Rs and a passion for driving scientific excellence?
We are currently advertising for the following three roles:

  • Programme Manager - Technology Development
  • Programme Manager - Challenge-Led Innovation
  • Regional Programme Manager - North West of England and Yorkshire

The closing date for all applications is Wednesday 13 July.



Automated monitoring of mouse behaviour in social home cage groups

A paper reporting a new automated home cage behavioural monitoring system for mice has been published in the journal Frontiers in Behavioural Neuroscience.

The Home Cage Analysis system longitudinally and non-invasively tracks individual mice group housed in standard caging. The equipment, now available to purchase from Actual Analytics, was developed through the NC3Rs Rodent Little Brother CRACK IT Challenge, and has already been used to identify previously unknown strain differences in behaviour.



Does age matter? Working group publish findings to improve reproducibility

A new paper in Laboratory Animals summarises the findings of an NC3Rs expert working group investigating the consideration of rodent age in studies.

The paper reviews the factors that affect the decision on the age of the animals used and how age can impact on scientific outcomes.



Animal models for CNS safety pharmacology under the spotlight

We have been working with the pharmaceutical industry to assess the relevance of rodent central nervous system (CNS) safety pharmacology studies in predicting what happens in first-in-human phase I studies. The finding published in Regulatory Toxicology and Pharmacology have important implications for reducing attrition in the drug development pipeline as well as animal use.



Call for submissions to EPAA 3Rs Science Prize

The European Partnership for Alternative Approaches to Animal Testing (EPAA) has launched its 2016 3Rs Science Prize.

Researchers based in Europe who are working on alternative methods and can demonstrate that their research furthers the 3Rs are eligible to apply. The prize consists of a grant of €10,000 which is awarded to their research institution.

The deadline for submissions is 23 September 2016 at 12 (noon) CET.


Solution: Comprehensive ex vivo platforms for experimental cancer medicine and drug development

Are you seeking new ex vivo human cancer models for studying basic cancer stem cell (CSC) biology or for the development of CSC-targeted therapeutics? If so, researchers from the Barts Cancer Centre, Queen Mary University of London would like to hear from you to help develop, validate and adopt their Experimental Cancer Medicine Platforms (ECMPs).



ZeGlobalTox landscape, much more than a simple Solution

Dr Davide D'Amico, Chief Executive Officer of ZeClinics provides his perspective on the impact of CRACK IT Solutions on the development and application of the ZeGlobalTox technology platform for drug development, and on ZeClinics business more generally.



Accelerating the acceptance of mathematical models as evidence in safety and efficacy decision making

14 – 15 September 2016: LONDON
We are working with the International Health and Environmental Sciences Institute (HESI) to host a two day workshop to accelerate the acceptance of mathematically-derived data to improve the predictivity of efficacy and safety testing for drugs and chemicals.

Participants are encouraged to submit poster abstracts highlighting specific research problems which would benefit from the input of mathematicians. The deadline for poster abstract submission is 3 August 2016.

Attendance is free, but registration is essential. The closing date for registration is 17 August 2016.



NC3Rs/IAT Animal Technicians' Symposium

22 September 2016: LONDON
Register for our one day symposium with the Institute of Animal Technology. Speakers from academia and industry will present the latest refinement opportunities and approaches to improving laboratory animal welfare.

Ten travel bursaries of up to £100 each are available. Participants are also encouraged to submit poster or presentation abstracts on a topic relevant to the 3Rs, with a £200 prize for the best poster. The deadline to submit abstracts is 19 August 2016.

Attendance is free, but registration is essential. The closing date for registration is 1 September 2016.


Find all of our most recent posts, along with our back catalogue here.


Announcing our new infrastructure grants

In her monthly blog, our Chief Executive Vicky Robinson reflects on our recent Infrastructure for Impact grant awards totalling £1 million.



The NC3Rs at Pint of Science 2016 - impressions and storify

We sponsored three events at this year's Pint of Science festival. In London Edinburgh and Southampton, researchers with NC3Rs funding discussed their work and the 3Rs.