NC3Rs e-newsletter - November 2016


£30k award for international 3Rs prize - competition now open


Each year the NC3Rs awards a prize to recognise an outstanding original contribution to scientific and technological advances in the 3Rs, published in the last three years. The award consists of a £28k prize grant and £2k personal award.


The competition is now open for applications with a deadline of 4pm (GMT) on Friday 9 December 2016. For further information on how to apply and examples of past winners see


The prize is sponsored by GlaxoSmithKline and the NC3Rs, and will be presented at an awards ceremony in London in March 2017.



New e-learning resource on laboratory animal euthanasia


Our new e-learning resource on “Humane Methods of Killing Laboratory Animals” is now available.


The free online resource, developed by Professor Paul Flecknell from Newcastle University, provides information on the principles of humane killing, the different methods available for mice and rats, and the legal requirements. The scenario-based training material covers EU Modules 6.1 and 6.3.




New quarterly newsletter on NC3Rs activities in Toxicology and Regulatory Sciences


We have launched this e-newsletter to keep the toxicology community updated on news from the NC3Rs Toxicology and Regulatory Sciences programme, including information on events, publications, funding opportunities, and relevant CRACK IT Challenges and Solutions.


To subscribe to Tox News email




New bioassay uses fruit fly to test for prion disease


Research funded by the NC3Rs has created a new model of prion disease, developed in the fruit fly.


Prion diseases are fatal neurodegenerative diseases that are transmissible across various mammalian species, occurring when there is a misfolding of the normal prion protein into a disease-specific form.


A team from the University of Cambridge, led by Dr Raymond Bujdoso, has shown that the fly model has the potential to be developed into a fast, low-cost diagnostic test for prion infectivity, avoiding the use of genetically modified mice or other vertebrate species in research.




We are looking to expand our dynamic team to further the development and uptake of 3Rs research tools and models. This is a great opportunity to lead and support our collaborations across the life sciences including with academia and industry.

The following positions are now open for applications:

  • Science Manager - Research Funding
    Salary: £27,355-£32,648 (plus London allowances)

  • Science Manager - Policy and Animal Welfare
    Salary: £27,355-£32,648 (plus London allowances)

  • Programme Manager - Toxicology and Regulatory Sciences: Environment (Maternity cover)
    Salary: £37,024 - £43,520 (plus London allowances)

  • Programme Manager - Technology Development (Maternity cover)
    Salary: £37,024 - £43,520 (plus London allowances)

  • Administrator - Funding Support
    Salary: £16,838 - £19,600 plus London allowances

The NC3Rs offers a wide range of benefits from a final salary pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and childcare vouchers.


Please visit for further information, including on how to apply.


The deadline for all applications is Friday 11 November.



Funding panel vacancies


We are currently inviting researchers, with relevant experience and expertise, to apply to join our Development and Impact, Grant, Studentship and Training Fellowship Assessment Panels, from January 2017.


Panel members will help to select the latest 3Rs technologies and approaches by reviewing applications from across a broad spectrum of scientific areas.


Deadline for applications: 4pm, 8 November 2016.




Skills and Knowledge Transfer grant scheme closing soon


We are accepting informal outline applications to our Skills and Knowledge Transfer grant scheme.


This new funding scheme supports the adoption of 3Rs models, tools and technologies into routine research practice, through the transfer of knowledge, skills and expertise.


Awards are for up to £75k and 12 months in duration.


Outlines must be submitted to the Office by 4pm, 25 November 2016.




Last chance to apply to CRACK IT Challenges 2016 funding


The 2016 CRACK IT Challenges are now open for applications:

  • Osteo-chip: An in vitro model to recapitulate the human osteoarthritic joint (Two Phase)
  • Retinal 3D: A physiologically-competent human 3D retinal model (Two Phase)
  • EASE: Eliminating surgical embryo transfer in mice (Single Phase)
  • Maximise: Reliable predictions for classifying mixtures of chemicals for acute oral toxicity, and skin and eye irritation (Single Phase)

Each of the Two Phase Challenges offers up to £1 million funding and a research contract for up to three years and the Single Phase Challenges offer up to £100k funding for up to one year.


The application deadlines are:
- Two Phase Challenges: 12pm, 9 November 2016.
- Single Phase Challenges: 12pm, 16 November 2016.



New Solution: Neuroinflammation and nociception
in a dish


Are you seeking new platforms for studying nociception and neuroinflammation which reduce your animal use? If so, researchers from the University of Turin, Italy are seeking partners to help further develop and validate their innovative spinal cord slice platforms (SCSPs).


They are especially keen to engage with (bio)pharmaceutical and academic partners able to provide candidate pain-controlling drugs/molecules to validate SCSPs for preclinical drug development and precision medicine, and to explore the utility of the slice model for investigating other disease models.




British Pharmacological Society annual meeting
13 - 15 December: LONDON


Dr Sam Jackson, NC3Rs Programme Manager for disease models, efficacy and safety pharmacology, will be co-chairing a session on organ-on-a-chip technology at the British Pharmacological Society's flagship annual meeting.


This session will focus on tools which improve disease modelling and safety pharmacology, as well as reducing the use of animal testing.


The closing date for registration is 2 December 2016.



All you wanted to know about being an NC3Rs Panel member... but were too afraid to ask


Professor Lucy Walker is an MRC Senior Non-clinical Research Fellow and Chair in Immune Regulation at University College London. She has been an NC3Rs Panel member since 2012.


In this blog, Professor Walker gives an insight into her role on the Panel.




Celebrating 12 years of working in toxicology and regulatory sciences


In her latest blog, our Chief Executive Vicky Robinson celebrates 12 years of the NC3Rs working in toxicology and the regulatory sciences.