NC3Rs e-newsletter - October 2017


New standards for publicly funded non-human primate research


For over a decade, our guidelines on ‘Non-human primate accommodation, care and use’ have set the standard for publicly funded research involving NHPs. Today we have launched a new and updated version of the guidelines.

Implementation of the principles in the guidelines is a condition of receiving funds for NHP research from the NC3Rs, MRC, BBSRC, EPSRC, Academy of Medical Sciences, Royal Society, Wellcome and other AMRC charities and funding bodies.




Social housing aids recovery from stressors in zebrafish


An NC3Rs-funded study has found that group-housed zebrafish show lower levels of stress and anxiety when they undergo stressful or painful procedures than those who are housed singly or in pairs.




Double-decker rodent telemetry


As part of our year of laboratory rodent welfare we are highlighting advances in animal welfare science and technology, and focusing on the adoption of best practice.

Recent research has shown that telemetry recordings can be made from rats socially-housed in double-decker cages, where they are able to engage in more natural behaviours such as upright standing and stretching.




Improving the quality of animal research with the EDA


Two new publications in Nature Methods and PLOS Biology describe how our Experimental Design Assistant (EDA) can assist researchers in designing robust and reliable experiments.




International 3Rs prize – nominations open


Our annual 3Rs prize, sponsored by GlaxoSmithKline, is awarded to the author(s) of a paper which has made an outstanding contribution to scientific and technological advances in the 3Rs, published in the last three years.

Consider nominating your colleagues or yourself for the award, which consists of a £28k prize grant and £2k personal award. Nominations must be submitted by 4pm (GMT) on Monday 4 December 2017.




Skills and Knowledge Transfer Scheme open for applications


We are accepting informal outline applications to our Skills and Knowledge Transfer Scheme. This funding scheme supports the adoption of 3Rs models, tools and technologies into routine research practice, through the transfer of knowledge, skills and expertise.

Awards are for up to £75k and 12 months in duration. Outlines must be submitted to the NC3Rs office by 4pm, 24 November 2017.




Register for our Skills and Knowledge Transfer Scheme webinar


To provide prospective applicants with further information on our Skills and Knowledge Transfer scheme and the application process, we will be hosting a webinar on 7 November 2017 from 2:30pm to 3:30pm.




Funding panel vacancies


We are currently inviting researchers, with relevant experience and expertise, to apply to join our Grant and Studentship Assessment Panels, from January 2018. Panel members will help to select the latest 3Rs technologies and approaches by reviewing applications from across a broad spectrum of scientific areas.

Deadline for applications: 4pm, 9 November 2017.




Last chance to apply to CRACK IT Challenges 2017 funding


This year there is £2.7 million available across three new toxicology-focused CRACK IT Challenges:

  • Challenge 26: “DARTpaths”: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects (Two Phase Challenge)
  • Challenge 27: “DoCE”: Dosing strategies for characterising in vitro dose-responses with increased relevance for in vivo extrapolation (Two Phase Challenge)
  • Challenge 28: “RespiraTox”: In silico model for predicting human respiratory irritation (Single Phase Challenge)

The deadline for applications for all Challenges is in November 2017.




£50k awarded in new CRACK IT Solutions funding


Moleculomics has been awarded seed funding through the NC3Rs CRACK IT Solutions partnering programme to collaborate with Dow Agrosciences on validating their in silico platform for better predicting liver toxicity of agrochemicals across species.