NC3Rs e-newsletter - September 2018


Introductory training on the 3Rs: time for a fresh approach


To support the training of scientists, technicians, students and others involved with animal research, we have produced a new video presentation introducing the 3Rs and their scientific importance. Find out how it can be used to encourage better engagement with the 3Rs.




New edition of Tox News published


The Tox News e-newsletter provides updates on our toxicology and regulatory sciences programme, including upcoming events, recent publications and funding opportunities. The latest edition is available to read online now.




The NC3Rs signs an MOU with the Animals in Science Regulatory Unit


We have recently signed a Memorandum of Understanding (MOU) with the UK Home Office’s Animals in Science Regulatory Unit, which formalises our relationship with them. This new agreement sets out a framework for effective collaboration and is part of our strategy to bridge the gap between the development and uptake of 3Rs approaches.




Vacancies at the NC3Rs


Do you have a demonstrable commitment to the 3Rs and a passion for driving scientific excellence? If you are seeking a new challenge in your career, we are currently advertising four vacancies within the NC3Rs:

  • Programme Manager – Research Funding (maternity cover)
  • Regional Programme Manager – North West and Yorkshire
  • Programme Manager – In Vitro Reporting Guidelines
  • Science Manager – Toxicology

Visit our website for further details, including the closing dates to apply for each role.




2018 CRACK IT Challenges competition now open


CRACK IT Challenges fund collaborations between industry, academia and SMEs to deliver 3Rs and commercial benefits through developing new products or improving business processes. This year’s competition is now open for applications, with a total of £2.45m available for the three Challenges.




New Solution: An automated test of recognition memory in rodents


Do you conduct recognition memory studies in rodents? Are you interested in automating these studies and reducing your animal use?


Researchers at Durham University have developed a semi-automated ‘continual trials’ approach for spontaneous object recognition tasks in which an animal can complete multiple trials in a single session with reduced handling and greater reproducibility. They are now seeking partners to help further develop and validate the apparatus.




£50k awarded in new CRACK IT Solutions funding


The developers of CombiDART at the University of Oxford have been awarded £50k seed funding through our CRACK IT Solutions partnering programme to further validate the system in the agrochemical sector. CombiDART is a low-cost approach that uses two non-vertebrate model systems to rapidly assess compounds for developmental and reproductive toxicity (DART).




Webinar: Skills and Knowledge Transfer scheme


Thinking of applying for funding through this year’s Skill and Knowledge Transfer scheme? On 8 November at 2.30pm (GMT) we will be hosting a webinar for prospective applicants that will provide further information on the scheme, including our new joint awards with Cancer Research UK, and how to submit a competitive application.




Mouse handling workshop: support for trainers, NTCOs and other named persons


26 November 2018 (Central London)


This free workshop will give attendees the tools and knowledge they need to implement refined mouse handling methods in their establishments. There will be opportunities to ask questions, explore potential barriers to uptake, consider solutions to these barriers, and partner with labs already implementing best practices.


Attendance is free, but registration is essential. The closing date for registration is 4pm on 12 November.




Primate Welfare Meeting 2018: programme now available online


15 November 2018 (Central London)


Our annual Primate Welfare Meeting keeps those working with non-human primates in research informed about the latest advances and best practices in their care and use. The programme for this year’s event features talks on a range of topics, flash poster presentations, a keynote lecture and plenty of networking opportunities.


Attendance is free, but registration is essential. The closing date for registration is 26 October.




Workshop: Application of non-animal approaches for decision-making in chemical safety assessment


10-11 December 2018 (Central London)


In collaboration with Unilever, we are hosting a two-day workshop exploring how in vitro and in silico approaches can inform safety and efficacy decision-making in product development programmes. Discussions will focus on what is needed to increase confidence in these new approaches.


Attendance is free, but registration is essential. The closing date for registration is 12 November and the closing date to submit a poster abstract is 2 November.




First-hand impressions from the 2018 NC3Rs Summer School


Our sixth annual Summer School took place in Manchester in July and brought together 24 PhD students who were either NC3Rs-funded or from the universities of Liverpool, Manchester and Sheffield. We spoke to some of this year’s attendees, who shared their impressions of the three eventful days.




First out of the Gate(way): a method for studying Alzheimer’s in vitro


In this new blog series, we will be profiling the first four papers published on the NC3Rs Gateway, our open access publishing platform hosted by F1000Research. We are starting with the first paper to pass peer review on the Gateway, co-authored by Drs Cara Croft and Wendy Noble, which describes a methodology for preparing brain slice cultures to study Alzheimer’s disease in place of rodent ageing studies.