Our impacts

We have positioned the UK at the forefront of 3Rs efforts globally. Funding cutting-edge research and world class scientists has been key to this. Here we showcase examples from across our portfolio to illustrate the breadth of the science we support and the 3Rs and scientific impacts delivered.

The case studies were originally published in our 2019 Research Review and 2019 CRACK IT Review. You can read both of these documents, along with our 2017 Studentship Review and 2013 Research Review on our dedicated Reviews area of the website.

Reducing the number of ferrets by eliminating the need for sentinel animals.
A Drosophila assay that is more sensitive than previously used mouse tests.
Replacing the use of calves for parasite production.
An improved surgical model to reduce inter-animal variability.
Using an in vitro model to study ossification and early bone formation.
Investigating cancer cell invasion and metastasis in zebrafish embryos.
Developing an Adverse Outcome Pathway to underpin the development and use of non-animal approaches.
Modelling the effects of therapeutics on the heart with a higher accuracy than animal models.
Using machine learning to refine and reduce animal studies in pancreatic cancer.
Avoiding challenging infection studies in non-human primates by using a cellular based in vitro assay.
Reducing the number of rodents needed in filariasis research using ultrasonography.
A non-invasive protocol for imaging sensory neurons in the Drosophila wing.
An ultralightweight wireless EEG recording device with animal welfare and technical advantages.
A system to continuously monitor and automatically analyse group-housed rodents in their home cage.
An organ-on-a-chip platform that models human renal tubular injury for use in nephrotoxicity studies.
An in silico model of the host response to chronic infection by Leishmania parasites.
A microfluidic device that eliminates the need for surgical embryo transfer in mice.
Non-mammalian testing for developmental and reproductive toxicology.
A new apparatus for industry use that reduces the use of mice in spontaneous recognition tasks.
A collaboration to validate an in vitro test for detecting botulinum neurotoxin.
Two collaborations to integrate an insect model into drug development and toxicity testing.
A chick egg embryo model that could replace some mouse xenograft studies in drug development.