We have positioned the UK at the forefront of 3Rs efforts globally. Funding cutting-edge research and world class scientists has been key to this. Here we showcase examples from across our portfolio to illustrate the breadth of the science we support and the 3Rs and scientific impacts delivered. These were published in our 2019 Research Review – you can read further impacts from our 2013 Research Review.
Reducing the number of ferrets by eliminating the need for sentinel animals.
An ultralightweight wireless EEG recording device with animal welfare and technical advantages.
A system to continuously monitor and automatically analyse group-housed rodents in their home cage.
An organ-on-a-chip platform that models human renal tubular injury for use in nephrotoxicity studies.
An in silico model of the host response to chronic infection by Leishmania parasites.
A microfluidic device that eliminates the need for surgical embryo transfer in mice.
Non-mammalian testing for developmental and reproductive toxicology.
A new apparatus for industry use that reduces the use of mice in spontaneous recognition tasks.
A collaboration to validate an in vitro test for detecting botulinum neurotoxin.
Two collaborations to integrate an insect model into drug development and toxicity testing.
A chick egg embryo model that could replace some mouse xenograft studies in drug development.