Development of a mechanistically informative genome-wide, replacement chemicals screening technology Principal Investigator: Professor Andrew Cossins, University of Liverpool Project grant
Refinement of therapeutic intervention in a mouse model of amyotrophic lateral sclerosis Principal Investigator: Dr Andrew Grierson, University of Sheffield Project grant
Pseudoislets as a model system to study beta cell dysfunction in diabetes Principal Investigator: Professor Peter Jones, King's College London Project grant
Modelling the human asthmatic airway by tissue engineering Principal Investigator: Professor Donna Davies, University of Southampton Project grant
Replacement of hamsters with physicochemical analytical methods for Leptospira vaccine batch potency testing Principal Investigator: Dr Nicholas Coldham, Veterinary Laboratories Agency Project grant
A tissue engineering approach to reduce animal use in renal development and renal organ replacement technology Principal Investigator: Professor Jamie Davies, University of Edinburgh Project grant
Reduction, refinement and replacement of animal use by clonal sampling Principal Investigator: Dr Phillip Jones, Hutchison-MRC Research Centre Project grant
Humane endpoints for rodenticide testing Principal Investigator: Dr Alan MacNicoll, Department for Environment Food & Rural Affairs Project grant
Metabolically competent stem cell systems: novel means to implement 3Rs in better drug safety assessment Principal Investigator: Professor Roland Wolf, University of Dundee Project grant
An in vitro model of the human alveolus to predict the efficacy of systemic antifungal therapy Principal Investigator: Professor William Hope, University of Manchester Project grant
Development of a reduced severity rat epilepsy model Principal Investigator: Dr Gavin Woodhall, Aston University Project grant
Non-invasive identification of individual Xenopus by photography and image processing Principal Investigator: Professor Matthew Guille, University of Portsmouth Project grant
In vitro multi-chamber systems for studying neural degeneration processes Principal Investigator: Professor Victor Perry, University of Southampton Project grant
Refinement of a mouse model of pulmonary embolism Principal Investigator: Dr Michael Emerson, Imperial College London Project grant
The use of honeybees to screen for toxins Principal Investigator: Dr Helen Thompson, Food and Environment Research Agency Project grant
An ex vivo mouse mandible culture model to study inflammatory bone disease Principal Investigator: Professor Alastair Sloan, Cardiff University Project grant
Development of alternatives to histamine sensitisation test for pertussis vaccines by in vitro biochemical and biological assays Principal Investigator: Dr Dorothy Xing, National Institute for Biological Standards and Control Project grant
Transcutaneous signal transmission without breaching the skin's natural barrier to infection Principal Investigator: Professor Stuart Baker, Newcastle University Project grant
Development of an in vitro model for the anterior region of the eye Principal Investigator: Dr Nigel Fullwood, Lancaster University Project grant
Development of a new human cell genotoxicity assay to reduce the use of live animals in drug development Principal Investigator: Professor Richard Walmsley, University of Manchester Project grant