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The reduction in animal usage by multiple antigen immunisation schedules

Principal Investigator: 

  • Dr Simon Smith

Institution: 

  • University of Sheffield
  • Project grant

Neoplasia and pain in laboratory animals

Principal Investigator: 

  • Dr John Roughan

Institution: 

  • Newcastle University
  • Project grant

A novel approach to the preclinical assessment of novel anti-cancer drugs

Principal Investigator: 

  • Professor Michael Bibby

Institution: 

  • University of Bradford
  • Project grant

3Rs of murine models of malaria infection: immunology meets experimental genetics

Principal Investigator: 

  • Dr Julius Hafalla

Institution: 

  • London School of Hygiene and Tropical Medicine
  • Project grant

Drosophila as a model to understand the role of glial cells in neurodegeneration

Institution: 

  • King's College London
  • Project grant

The assessment of pain using facial expressions in laboratory mice, rats, rabbits and macaques

Principal Investigator: 

  • Dr Matt Leach

Institution: 

  • Newcastle University
  • Project grant

Wireless high-bandwidth trans-cutaneous signal transmission

Principal Investigator: 

  • Professor Stuart Nicolas Baker

Institution: 

  • Newcastle University
  • Project grant

Using the Drosophila fly intestine to investigate Wnt targets in vivo

Principal Investigator: 

  • Dr Owen Sansom

Institution: 

  • University of Glasgow
  • Project grant

FIGCS: An in vitro model to replace ecotoxicity testing of fish to pharmaceuticals

Principal Investigator: 

  • Professor Christer Hogstrand

Institution: 

  • King's College London
  • Project grant

Replacement of animals in cancer drug development by using 3D in vitro functional assays for increased predictive power

Principal Investigator: 

  • Dr Louis Chesler

Institution: 

  • Institute of Cancer Research
  • Project grant

2Rs (refining and reducing) of animal models of multiple sclerosis

Principal Investigator: 

  • Professor David Baker

Institution: 

  • Queen Mary University of London
  • Project grant

Replacing, refining and reducing animal usage in epilepsy research using a non-sentient model

Principal Investigator: 

  • Professor Robin Williams

Institution: 

  • Royal Holloway University of London
  • Project grant

Applying the 3Rs to elucidate the mechanisms of tau pathology using DRG neurons in culture

Principal Investigator: 

  • Professor Maria Grazia Spillantini

Institution: 

  • University of Cambridge
  • Project grant

A 3D air-liquid interface airway epithelial cell model to study pathogen interactions within the bovine respiratory tract

Principal Investigator: 

  • Dr Robert Davies

Institution: 

  • University of Glasgow
  • Project grant

The snail assay as an alternative to the rodent Hershberger assay for detecting androgens and anti-androgens

Principal Investigator: 

  • Dr Susan Jobling

Institution: 

  • Brunel University
  • Project grant

A chronic model of epilepsy in organotypic brain slice cultures of the rat entorhinal cortex

Principal Investigator: 

  • Professor Roland Jones

Institution: 

  • University of Bath
  • Project grant

Development of cell based assays as replacement assays for Botulinum toxins and antitoxins

Principal Investigator: 

  • Dr Dorothea Sesardic

Institution: 

  • National Institute for Biological Standards and Control
  • Project grant

Refining models of fibrotic lung disease

Principal Investigator: 

  • Dr Gisli Jenkins

Institution: 

  • University of Nottingham
  • Project grant

Development of a non-lethal sampling method to monitor immune response and disease progression in salmonid fish

Principal Investigator: 

  • Dr Bertrand Collet

Institution: 

  • Marine Scotland Science
  • Project grant

Development and validation of an automated test of animal affect and welfare for laboratory rodents

Principal Investigator: 

  • Professor Michael Mendl

Institution: 

  • University of Bristol
  • Project grant

Development of alternatives to histamine sensitisation test for pertussis vaccines by in vitro biochemical and biological assays

Principal Investigator: 

  • Dr Dorothy Xing

Institution: 

  • National Institute for Biological Standards and Control
  • Project grant

Non-invasive identification of individual Xenopus by photography and image processing

Principal Investigator: 

  • Professor Matthew Guille

Institution: 

  • University of Portsmouth
  • Project grant

Reduction, refinement and replacement of animal use by clonal sampling

Principal Investigator: 

  • Dr Phillip Jones

Institution: 

  • Hutchison-MRC Research Centre
  • Project grant

Metabolically competent stem cell systems: novel means to implement 3Rs in better drug safety assessment

Principal Investigator: 

  • Professor Charles R Wolf

Institution: 

  • University of Dundee
  • Project grant

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