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Refinement of therapeutic intervention in a mouse model of amyotrophic lateral sclerosis

Principal Investigator: 

  • Dr Andrew Grierson

Institution: 

  • University of Sheffield
  • Project grant

Replacement of hamsters with physicochemical analytical methods for Leptospira vaccine batch potency testing

Principal Investigator: 

  • Dr Nicholas Coldham

Institution: 

  • Veterinary Laboratories Agency
  • Project grant

Development and validation of mechanisms-based in vitro transformation assays for carcinogen screening

Principal Investigator: 

  • Professor Robert Newbold

Institution: 

  • Brunel University
  • Project grant

Carotid artery endothelial growth: a novel in vitro assay

Principal Investigator: 

  • Dr Atticus H Hainsworth

Institution: 

  • St George's University of London
  • Project grant

Development of leucocyte cell lines for immunological research in teleost fish

Principal Investigator: 

  • Dr Jun Zou

Institution: 

  • University of Aberdeen
  • Project grant

Refinement of animal studies on emesis by defining human biomarkers of nausea

Principal Investigator: 

  • Professor Qasim Aziz

Institution: 

  • Queen Mary University of London
  • Project grant

Inducible SAA transgenic mice: a refined model of human amyloidosis

Principal Investigator: 

  • Dr Paul Simons

Institution: 

  • University College London
  • Project grant

Transgenic ES Cell Differentiation Systems to replace Transgenic Mouse Analysis of Tissue Specific Regulatory Elements

Principal Investigator: 

  • Dr Berthold Gottgens

Institution: 

  • University of Cambridge
  • Project grant

Derivation of conditionally immortalised mouse DRG cell lines

Principal Investigator: 

  • Dr Mohammed Nassar

Institution: 

  • University of Sheffield
  • Project grant

A 3D tissue model of breast morphogenesis for replacing animals in testing for endocrine disrupting substances

Principal Investigator: 

  • Professor Charles Vyvyan Howard

Institution: 

  • University of Ulster
  • Project grant

Development of in vitro assays to determine vaccine efficacy in fish

Principal Investigator: 

  • Professor Christopher Secombes

Institution: 

  • University of Aberdeen
  • Project grant

An advanced model for neurodegeneration studies in the fruit fly Drosophila melanogaster

Principal Investigator: 

  • Dr Ezio Rosato

Institution: 

  • University of Leicester
  • Project grant

Replacement of animal models for tumour biology with a multifunctional microfluidic-based approach

Principal Investigator: 

  • Professor John Greenman

Institution: 

  • University of Hull
  • Project grant

Development of a reduced severity rat epilepsy model

Principal Investigator: 

  • Dr Gavin Woodhall

Institution: 

  • Aston University
  • Project grant

Developing an in vitro approach to study transmission of respiratory viruses

Principal Investigator: 

  • Professor Wendy Barclay

Institution: 

  • Imperial College London
  • Project grant

Validating reward-related behaviour for welfare assessment, and improving welfare through increased predictability of events

Principal Investigator: 

  • Professor Hannah Buchanan-Smith

Institution: 

  • University of Stirling
  • Project grant

Use of PrP transgenic Drosophila to measure mammalian prion infectivity

Institution: 

  • University of Cambridge
  • Project grant

Establishment of consensual husbandry protocols for laboratory Xenopus laevis using novel physiological and behavioural techniques

Institution: 

  • University of Chester
  • Project grant

Reduction & refinement in animal models of neuropathic pain: using systematic review & meta-analysis

Principal Investigator: 

  • Dr Emily Sena

Institution: 

  • University of Edinburgh
  • Project grant

eGUT: a Tool for Predictive Computer Simulation of the Gut Microbiota and Host Interactions

Principal Investigator: 

  • Dr Jan-Ulrich Kreft

Institution: 

  • University of Birmingham
  • Project grant

Development of computational models of bone formation and resorption to predict changes in bone in preclinical intervention studies

Principal Investigator: 

  • Dr Ilaria Bellantuono

Institution: 

  • University of Sheffield
  • Project grant

Assessing cumulative severity in macaques used in neuroscience research

Principal Investigator: 

  • Professor Melissa Bateson

Institution: 

  • Newcastle University
  • Project grant

The detection, assessment and alleviation of pain in laboratory zebrafish

Principal Investigator: 

  • Dr Lynne Sneddon

Institution: 

  • University of Liverpool
  • Project grant

Assessing welfare in fish: the answer is in the water!

Principal Investigator: 

  • Dr Ioanna Katsiadaki

Institution: 

  • Centre for Environment Fisheries and Aquaculture Science (CEFAS)
  • Project grant

Quantifying the behavioural and facial correlates of pain in laboratory macaques

Principal Investigator: 

  • Dr Sarah-Jane Vick

Institution: 

  • University of Stirling
  • Project grant

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