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Reducing mouse number in complex genetic experiments

Principal Investigator: 

  • Dr Pieter Hohenstein

Institution: 

  • University of Edinburgh
  • Project grant

Stem cell-derived cardiomyocytes for detection of cardiotoxicity in cancer therapeutics

Principal Investigator: 

  • Professor Sian Harding

Institution: 

  • Imperial College London
  • Project grant

Human pluripotent stem cell cardiomyocytes and hepatocytes with engineered genotypes for drug safety evaluation

Principal Investigator: 

  • Professor Chris Denning

Institution: 

  • University of Nottingham
  • Project grant

Zebrafish behavioural assays to identify genetic mechanisms underlying drug seeking and addiction

Principal Investigator: 

  • Dr Caroline Brennan

Institution: 

  • Queen Mary University of London
  • Project grant

Highly differentiated cultures of ferret airway epithelium for the study of respiratory viruses, including influenza

Principal Investigator: 

  • Professor Wendy Barclay

Institution: 

  • Imperial College London
  • Project grant

The human tumour micro-environment modelled in in vitro biomatrices and applied to cancer drug discovery

Principal Investigator: 

  • Dr Anna Grabowska

Institution: 

  • University of Nottingham
  • Project grant

Assessing the welfare of mice used in cancer research

Principal Investigator: 

  • Dr John Roughan

Institution: 

  • Newcastle University
  • Project grant

The use of honeybees to screen for toxins

Principal Investigator: 

  • Dr Helen M Thompson

Institution: 

  • Food and Environment Research Agency
  • Project grant

Replacement of murine transplantation assays by 3D in vitro substitutes for the assessment of therapeutic responses of cancer stem cells.

Principal Investigator: 

  • Professor Ian MacKenzie

Institution: 

  • Queen Mary University of London
  • Project grant

Reduction and refinement of murine models of bacterial infection

Principal Investigator: 

  • Professor Shiranee Sriskandan

Institution: 

  • Imperial College London
  • Project grant

Reducing and replacing mouse use to model the human platelet response in vivo

Institution: 

  • Imperial College London
  • Project grant

Replacement in vitro assays for the quantification of clostridial vaccine antigens

  • Project grant

The development of an in vitro model of central nervous system injury to identify factors which promote repair

Principal Investigator: 

  • Professor Susan Barnett

Institution: 

  • Unversity of Glasgow
  • Project grant

An ex vivo mouse mandible culture model to study inflammatory bone disease

Principal Investigator: 

  • Professor Alastair Sloan

Institution: 

  • Cardiff University
  • Project grant

Embryonic stem cell-derived cardiomyocytes as a model system for cardiac investigations

Principal Investigator: 

  • Professor Sian Harding

Institution: 

  • Imperial College London
  • Project grant

Refinement of a mouse model of pulmonary embolism

Institution: 

  • Imperial College London
  • Project grant

Development of a new tissue-friendly head implant for use in awake, behaving monkey studies

Principal Investigator: 

  • Professor Roger Lemon

Institution: 

  • University College London
  • Project grant

Development of an air-interface in vitro organ culture model (IVOC) of bovine respiratory epithelium

Principal Investigator: 

  • Dr Alexander W Tucker

Institution: 

  • University of Cambridge
  • Project grant

Maintenance of Lutzomyia longipalpis colonies using an artificial membrane blood-feeding method

Principal Investigator: 

  • Professor Richard Ward

Institution: 

  • Keele University
  • Project grant

The behaviour of laboratory mice as an indicator of welfare state in genetically modified mice

Principal Investigator: 

  • Professor Christine Nicol

Institution: 

  • University of Bristol
  • Project grant

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