CleanCut - Developing a human in vitro model to assess the safety of gene edited human haemopoietic stem cells
Contractor:
Dr Alessandro Rotilio, MOAB srl
- CRACK IT Challenge
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Transgene Track - An imaging approach to track AAV gene therapies and CAR T-cells in vivo
Contractor:
Professor Wolfgang Weber, Technical University of Munich
- CRACK IT Challenge
ImmuLiver – An immunologically-competent in vitro model of the human liver for the assessment of Yellow Fever vaccine attenuation
Contractor:
Professor Lyle Armstrong, Newcells Biotech Ltd
- CRACK IT Challenge
RaTS - Developing a device for objective monitoring of rheumatoid arthritis progression in rodents
Contractor:
Associate Professor Martin Hedegaard, University of South Denmark (SDU)
- CRACK IT Challenge
Generation of functionally mature pancreatic organoids as a replacement strategy for animal-models of pancreatitis and pancreatic cancer
Principal Investigator:
Dr Jean-Francois Darrigrand
Institution:
- King's College London
- Fellowship
Understanding brain regeneration in a zebrafish larval model of intracerebral haemorrhage
Principal Investigator:
Dr Siobhan Crilly
Institution:
- University of Manchester
- Fellowship
Preclinical Radiomics: A novel approach linking imaging with biological outcomes in mouse models
Principal Investigator:
Miss Kathryn Brown
Institution:
- Queen's University Belfast
- Fellowship
Optimisation and validation of 3D models of progressive human lung fibrosis
Principal Investigator:
- Mr Joseph Bell
Institution:
- University of Southampton
- Fellowship
Supporting the adoption of microphysiological systems for COVID research
Current contact:
Dr Anthony Holmes
- Office-led project
Replacement of animal use in measuring cardiomyocyte response to drug safety profiling using a novel NMR metabolomics technology
Principal Investigator:
Dr Rachel Oldershaw
Institution:
- University of Liverpool
- PhD Studentship
Investigating biomechanical responses in healthy and diseases ageing cartilage - a tissue engineering approach
Principal Investigator:
Dr Katarzyna Pirog
Institution:
- Newcastle University
- PhD Studentship
Targeted protein degradation as a novel approach to study protein function in human platelets
Principal Investigator:
Professor Ingeborg Hers
Institution:
- University of Bristol
- PhD Studentship
A novel in vitro reporter system for blood stem cell activity
Principal Investigator:
Dr David Kent
Institution:
- University of York
- PhD Studentship
Refining the tagging of wild fish and sharks
Principal Investigator:
Dr Matthew Witt
Institution:
- University of Exeter
- PhD Studentship
Understanding how altered brain metabolism causes mitochondrial disease
Principal Investigator:
Dr Joseph Bateman
Institution:
- King's College London
- PhD Studentship
Combining a fully synthetic hydrogel with human intestinal organoids to model pathological matrix remodelling in Inflammatory Bowel Disease
Principal Investigator:
Dr Eileen Gentleman
Institution:
- King's College London
- PhD Studentship
A novel Drosophila model of chronic inflammatory lung disease to explore airway damage, inflammation and infection in vivo
Principal Investigator:
Dr Helen Weavers
Institution:
- University of Bristol
- PhD Studentship
3D bioprinted microtissues to develop patient-specific non-animal technologies (NAT) in cancer drug development
Principal Investigator:
Dr Deepali Pal
Institution:
- Northumbria University
- PhD Studentship
Insects as models to study wound healing, infection and the wound microbiome
Principal Investigator:
Dr Ronan McCarthy
Institution:
- Brunel University
- PhD Studentship
A 3Rs approach to investigate the feto-maternal interface: visualisation of pathogen and antibody in a 3D in vitro human placental model
Principal Investigator:
Dr Marie Yang
Institution:
- University of Liverpool
- PhD Studentship
Development and validation of 3D in vitro dormant myeloma cell models to reduce and replace animal studies
Principal Investigator:
Dr Michelle Lawson
Institution:
- University of Sheffield
- PhD Studentship
Drug risk assessment and repurposing using biomimetic chromatography and body-on-chip technology
Principal Investigator:
Dr Adriana Tavares
Institution:
- University of Edinburgh
- PhD Studentship
Review of animal use requirements in WHO biologics guidelines
Current contact:
Dr Anthony Holmes
- Office-led project
Preneoplastic Pancreatic (PanIN) Organoids as an in vitro Model of Pancreatic Cancer Progression
Principal Investigator:
Dr Pedro Perez-Mancera
Institution:
- University of Liverpool
- Project grant