Developing an in vitro repeat-dose test as a 3Rs approach to detect non-genotoxic carcinogens
Principal Investigator:
Professor Gareth Jenkins
Institution:
- Swansea University
- PhD Studentship
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Recreating thrombosis models using tissue-engineered arterial constructs: A novel method to reduce and replace mice used in platelet research
Principal Investigator:
Dr Alan Harper
Institution:
- Keele University
- PhD Studentship
Refining, reducing and replacing non-model amphibian experiments on amphibian infectious diseases
Principal Investigator:
Dr Trenton Garner
Institution:
- Zoological Soc London Inst of Zoology
- PhD Studentship
Using zebrafish embryos to identify genes that protect against atherosclerosis
Principal Investigator:
Professor Paul Evans
Institution:
- University of Sheffield
- PhD Studentship
Refinement of soft tissue targeting and alignment protocols is small animal radiotherapy using an injectable fiducial marker
Principal Investigator:
Dr Karl Butterworth
Institution:
- Queen's University Belfast
- PhD Studentship
Moving the Adverse Outcome Pathways Framework towards Practical Utility by Integrating Compound Profiling Data and Using Deep Learning
Principal Investigator:
Dr Andreas Bender
Institution:
- University of Cambridge
- PhD Studentship
Replacing animal models in fungal pathogen research: An in vitro Titan virulence assay for the human fungal pathogen Cryptococcus neoformans
Principal Investigator:
Dr Elizabeth Ballou
Institution:
- University of Birmingham
- PhD Studentship
Validating the cross-species comparative in silico platform (CRISP)
Contractor:
Dr Will Krawszik
- CRACK IT Solution
3D hiPSC derived laminated retinal model as a tool for toxicology studies
Contractor:
Professor Lyle Armstrong, Newcells Biotech Ltd
- CRACK IT Challenge
Microfluidic Automated Platform for Osteoarthritis Drug Screening (MA-PODS)
Contractor:
Professor Anne Dickinson, Alcyomics Ltd
- CRACK IT Challenge
Development of an AOP for cardiotoxicity mediated by the blockade of L-type calcium channel
Principal Investigator:
Dr Luigi Margiotta-Casaluci
Institution:
- Brunel University
- Strategic grant
A chicken primary B cell culture model to study the pathogenesis and improve the control of immunosuppressive viruses of poultry
Principal Investigator:
Dr Andrew Broadbent
Institution:
- The Pirbright Institute
- Project grant
Ex vivo model for the study of epicardium-targeted therapies
Principal Investigator:
Dr Paola Campagnolo
Institution:
- University of Surrey
- Project grant
Identifying more clinically effective analgesic regimens and potential strain differences in pain perception in mice using a novel Operant Pain Assay
Principal Investigator:
Dr Matt Leach
Institution:
- Newcastle University
- Project grant
A technique to test novel methods of controlling poultry red mite in hens without performing field-scale trials
Principal Investigator:
Dr Alasdair Nisbet
Institution:
- Moredun Research Institute
- Project grant
A comprehensive in silico approach to measure spatio-temporal changes of bone tissue in mouse models of osteoporosis and osteoarthritis
Principal Investigator:
Dr Enrico Dall'Ara
Institution:
- University of Sheffield
- Project grant
Development, validation and application of enhanced-welfare technology for wild small mammal research
Principal Investigator:
Dr Sarah Knowles
Institution:
- University of Oxford
- Project grant
Reducing the animal cost of CRISPR/Cas9 mutagenesis
Principal Investigator:
Dr Benjamin Davies
Institution:
- University of Oxford
- Project grant
Quantifying the potential of skin swabbing as a refinement for DNA sampling of laboratory fish
Principal Investigator:
Dr William Norton
Institution:
- University of Leicester
- Project grant
Replacing liver cancer models by modeling human liver cancer in vitro
Principal Investigator:
Dr Meritxell Huch
Institution:
- University of Cambridge
- Project grant
Improving the predictive power of models for cancer research
Current contact:
Dr Anthony Holmes
- Office-led project
Transfer of a non-human primate (NHP) in vitro functional assay for the early evaluation of TB vaccine candidates and the associated immune response
Principal Investigator:
Dr Rachel Tanner
Institution:
- University of Oxford
- Skills and Knowledge Transfer grant
High-throughput in vitro culture system for Cryptosporidium oocysts: replacing animals in research
Principal Investigator:
Professor Joanne Cable
Institution:
- Cardiff University
- Skills and Knowledge Transfer grant
The use of PrP transgenic Drosophila to replace and reduce mice in the bioassay of mammalian prions
Principal Investigator:
Dr Raymond Bujdoso
Institution:
- University of Cambridge
- Skills and Knowledge Transfer grant