CleanCut - Developing a human in vitro model to assess the safety of gene edited human haemopoietic stem cells
Contractor:
Dr Alessandro Rotilio, MOAB srl
- CRACK IT Challenge
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Transgene Track - An imaging approach to track AAV gene therapies and CAR T-cells in vivo
Contractor:
Professor Wolfgang Weber, Technical University of Munich
- CRACK IT Challenge
ImmuLiver – An immunologically-competent in vitro model of the human liver for the assessment of Yellow Fever vaccine attenuation
Contractor:
Professor Lyle Armstrong, Newcells Biotech Ltd
- CRACK IT Challenge
RaTS - Developing a device for objective monitoring of rheumatoid arthritis progression in rodents
Contractor:
Associate Professor Martin Hedegaard, University of South Denmark (SDU)
- CRACK IT Challenge
Sharp and to the Point: Developing a device for injections in mice that avoids the re-use of needles
Contractor:
Mr Ian Quirk, Active Needle Technology Ltd
- CRACK IT Challenge
Developing an automated apparatus for continual trials recognition memory in rodents
Contractor:
Dr Alex Easton
- CRACK IT Solution
DARTpaths: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects
Contractor:
Professor Raymond Pieters, University of Applied Sciences Utrecht (UASU)
- CRACK IT Challenge
Validating CombiDART in the agrochemical sector
Contractor:
Professor Alison Woollard
- CRACK IT Solution
Development and evaluation of the Animal Welfare Assessment Grid (AWAG)
Contractor:
Mr Mike Dennis, Public Health England
- CRACK IT Solution
RespiraTox: In silico model for predicting human respiratory irritation
Contractor:
Dr Sylvia Escher, Fraunhofer ITEM
- CRACK IT Challenge
A new sensor platform combining plastic antibodies with simple thermal detection
Contractor:
Dr Marloes Peeters
- CRACK IT Solution
Validating the cross-species comparative in silico platform (CRISP)
Contractor:
Dr Will Krawszik
- CRACK IT Solution
3D hiPSC derived laminated retinal model as a tool for toxicology studies
Contractor:
Professor Lyle Armstrong, Newcells Biotech Ltd
- CRACK IT Challenge
Microfluidic Automated Platform for Osteoarthritis Drug Screening (MA-PODS)
Contractor:
Professor Anne Dickinson, Alcyomics Ltd
- CRACK IT Challenge
Using chicken eggs to advance the 3Rs in cancer drug discovery
Contractor:
Dr Jean Viallet
- CRACK IT Solution
Design, Fabrication and Testing of a Mouse Embryo Culture Chip
Contractor:
Dr Virginia Pensabene, University of Leeds
- CRACK IT Challenge
Integrated web platform for agro-chemical formulation toxicity classification and data sharing
Contractor:
Professor Jonathan Timmis, SimOmics Ltd
- CRACK IT Challenge
Neuroinflammation and nociception in a dish
Contractor:
Professor Adalberto Merighi
- CRACK IT Solution
Non-invasive in vivo tissue imaging with functional optical coherence tomography (OCT)
Contractor:
Professor Zhihong Huang
- CRACK IT Solution
TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Demuris)
Contractor:
Dr Olivia Champion
- CRACK IT Solution
TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Envigo)
Contractor:
Dr Olivia Champion
- CRACK IT Solution
Developing an ethical, sustainable, human sensory neuron culture model for use in therapeutic pain research
Contractor:
Professor Andrew Hart, NHS Greater Glasgow & Clyde
- CRACK IT Challenge
3D hiPSC derived skin model and in-silico skin modelling of metabolism
Contractor:
Newcells Biotech Ltd
- CRACK IT Challenge
A human IPS cell model for gene therapy vector safety evaluation
Contractor:
GeneWerk GmbH
- CRACK IT Challenge