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The development of cell lines relevant for the discovery of new treatments for bipolar affective disorder

  • CRACK IT Challenge

Engineered 2D & 3D hiPSC-CM platforms to detect cardiovascular safety liabilities

  • CRACK IT Challenge

Non-invasive diffusion tracking in pharmacokinetics

  • CRACK IT Solution

Refinement of rodent and non-rodent housing during telemetry recordings

  • Office-led project

DictyMyc: Using Dictyostelium to study the genetic basis of Mycobacterium bovis intracellular infection

Institution: 

  • University of Surrey
  • Strategic grant

Developing and validating an in vitro mycobacterial challenge model to facilitate TB vaccine research and minimise in vivo challenge

Institution: 

  • University of Oxford
  • Strategic grant

A bovine alveolus model to replace cattle in the study of host-pathogen interactions in bovine tuberculosis

Institution: 

  • University of Surrey
  • Strategic grant

An integrative Dictyostelium, C. elegans and zebrafish approach to assess DART

  • CRACK IT Challenge

An early screen for emetic liability of NCEs using the amoeba Dictyostelium

  • CRACK IT Solution

Review of global data requirements for plant protection products

  • Office-led project

Reducing repetition of regulatory vertebrate ecotoxicology studies

  • Office-led project

Utilising QSARs to predict fish acute toxicity of pesticide metabolites

  • Office-led project

Applying the one concentration approach in fish bioaccumulation studies

  • Office-led project

Applying the threshold approach in fish acute toxicity studies

  • Office-led project

Assessing the need for chronic fish studies on formulated pesticides

  • Office-led project

Probing in vivo parasite biology in vitro

Institution: 

  • Queen's University Belfast
  • Project grant

Human stem cell derived neurones and astrocytes as an in vitro model of human prion infection and replication

Institution: 

  • University of Edinburgh
  • Project grant

Development and validation of a rodent touchscreen battery for assessing motivation and affective state

Institution: 

  • University of Cambridge
  • Project grant

Modelling liver fibrosis using human Induced Pluripotent Stem Cells

Institution: 

  • University of Cambridge
  • Project grant

Development of a tetanus-sensitive cell line for assaying tetanus toxin activity

Institution: 

  • University of Sheffield
  • Project grant

A multi-cellular 3D model of human breast tissue to replace rodent xenograft models in breast cancer research

Institution: 

  • University of Nottingham
  • Project grant

Reducing animal numbers in tasks of memory

  • CRACK IT Solution

Advancing the development and application of non-animal technologies (NATs)

  • Office-led project

Replacing, reducing and refining the use of animals in anti-filarial drug testing

Principal Investigator: 

  • Dr Joseph Turner

Institution: 

  • Liverpool School of Tropical Medicine
  • PhD Studentship

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