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Development of novel imaging agents for the prospective quantification of joint damage to reduce animal numbers in osteoarthritis research

Principal Investigator: 

  • Professor Tonia Vincent

Institution: 

  • University of Oxford
  • Project grant

Novel biomarker platform for a 3Rs approach to assessment of developmental and reproductive toxicity

Principal Investigator: 

  • Dr Catherine Pears

Institution: 

  • University of Oxford
  • Project grant

Mechanisms of intestinal epithelial responses to inflammatory modulators

Principal Investigator: 

  • Professor Inke Nathke

Institution: 

  • University of Dundee
  • Project grant

The Drosophila adult intestine as a model for radiation tolerance and resistance

Principal Investigator: 

  • Dr Joaquin de Navascues

Institution: 

  • Cardiff University
  • Pilot study grant

Determining the source of variability within experimental stroke models

Principal Investigator: 

  • Dr Claire Gibson

Institution: 

  • University of Leicester
  • Pilot study grant

Refining the mouse model of footpad immunisation and infection

Principal Investigator: 

  • Dr Owain Millington

Institution: 

  • University of Strathclyde
  • Pilot study grant

Development of human ex vivo bone-tumour niche for the study of cancer bone disease

Principal Investigator: 

  • Dr James Edwards

Institution: 

  • University of Oxford
  • Pilot study grant

EFucci an atlas of proliferation to reduce mouse usage in embryonic proliferation assays

Principal Investigator: 

  • Dr Richard Mort

Institution: 

  • MRC Human Genetics Unit
  • University of Edinburgh
  • Pilot study grant

Generating zebrafish models of human eye movement disorders to replace mouse models

Principal Investigator: 

  • Dr Ivana Poparic

Institution: 

  • King's College London
  • Fellowship

Molecularly Imprinted Nanoparticles (MIP NPs) as non-animal antibodies substitutes for detection of viruses

Principal Investigator: 

  • Dr Alessandro Poma

Institution: 

  • University College London
  • Fellowship

Contribution of autophagy to the maintenance, invasion and metastasis of melanoma stem-like sub populations.

Institution: 

  • Newcastle University
  • Fellowship

Ultrasound mediated bioluminescence tomography for high sensitivity, high spatial resolution 3D imaging

Principal Investigator: 

  • Professor Stephen Morgan

Institution: 

  • University of Nottingham
  • Strategic grant

Targeted, radiolabelled near-infrared quantum dots for high sensitivity and resolution, dual modality imaging of human tumours in mice

Principal Investigator: 

  • Dr Anna Grabowska

Institution: 

  • University of Nottingham
  • Strategic grant

Non-invasive real-time bioluminescence imaging in living mice to interrogate transcription factor activity and fate of engrafted stem cells

Institution: 

  • Manchester Metropolitan University
  • Strategic grant

Labelled IMS TAG Proteins for Quantitative Mass Spectrometry Imaging

Principal Investigator: 

  • Professor Malcolm Clench

Institution: 

  • Sheffield Hallam University
  • Strategic grant

Implanted optical imaging laboratories for deep-tissue in vivo imaging

Principal Investigator: 

  • Professor Andrew Harvey

Institution: 

  • University of Glasgow
  • Strategic grant

iPS cells from ALS patients: Towards replacing animal models for ALS

Principal Investigator: 

  • Dr Vasanta Subramanian

Institution: 

  • University of Bath
  • Project grant

A compartmentalised chamber for the in vitro study and manipulation of axon degeneration

Principal Investigator: 

  • Professor Victor H Perry

Institution: 

  • University of Southampton
  • Project grant

Drosophila as a model for Alzheimer's disease

Principal Investigator: 

  • Dr Kevin Moffat

Institution: 

  • University of Warwick
  • Project grant

Development and validation of in vitro methods for assaying cancer stem cell responses to therapeutic challenge

Principal Investigator: 

  • Professor Ian MacKenzie

Institution: 

  • Queen Mary University of London
  • Project grant

Engineering fully functional, integrated skeletal muscle

Principal Investigator: 

  • Professor Mark Lewis

Institution: 

  • Loughborough University
  • Project grant

Development of induced pluripotent stem (iPS) cells from mutant mouse models in order to reduce animal use

Principal Investigator: 

  • Dr Majid Hafezparast

Institution: 

  • University of Sussex
  • Project grant

Establishment and validation of a stable, cell-based diabetic wound bioassay

Principal Investigator: 

  • Professor Phil Stephens

Institution: 

  • Cardiff University
  • Project grant

Validating a sexual development test using the 3-spined stickleback for addressing the 3Rs in fish toxicity testing

Principal Investigator: 

  • Dr Ioanna Katsiadaki

Institution: 

  • Centre for Environment Fisheries and Aquaculture Science (CEFAS)
  • Project grant

Development of a mechanistically informative genome-wide, replacement chemicals screening technology

Principal Investigator: 

  • Professor Andrew Cossins

Institution: 

  • University of Liverpool
  • Project grant

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