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Exploitation of an ex vivo disease model to characterise early events in retinal degeneration

Institution: 

  • University of Southampton
  • PhD Studentship

SEARCHbreast: A virtual resource to facilitate sharing breast cancer materials and knowledge to benefit the 3Rs

Principal Investigator: 

  • Professor Valerie Speirs

Institution: 

  • University of Leeds
  • Infrastructure grant

SyRF: the CAMARADES/NC3Rs in vivo systematic review and meta-analysis facility

Principal Investigator: 

  • Professor Malcolm Macleod

Institution: 

  • University of Edinburgh
  • Infrastructure grant

Using C. elegans to produce proteins from parasitic nematodes for research and therapeutic use

Principal Investigator: 

  • Dr David Weinkove

Institution: 

  • Durham University
  • Pilot study grant

Single dose acute toxicity studies

  • Office-led project

Reducing the number of non-human primates in research by developing a rodent model of selective attention

Principal Investigator: 

  • Dr Samuel Solomon

Institution: 

  • University College London
  • Pilot study grant

Replacement of murine transplantation assays by 3D in vitro substitutes for the assessment of therapeutic responses of cancer stem cells.

Principal Investigator: 

  • Professor Ian MacKenzie

Institution: 

  • Queen Mary University of London
  • Project grant

Establishment of non-transformed, continuously growing, alternatively activated mouse macrophage cell lines

Principal Investigator: 

  • Dr Gyorgy Fejer

Institution: 

  • University of Southampton
  • Pilot study grant

Development of an in vitro screening system to minimise animal use in the search for factors that modulate (re)myelination

Institution: 

  • University of Glasgow
  • Pilot study grant

Towards an in vitro system of predictive biomarkers of in vivo liposome efficacy

Principal Investigator: 

  • Dr Andrew Devitt

Institution: 

  • Aston University
  • Pilot study grant

Novel approaches to immortalise salmon fish cells

Principal Investigator: 

  • Dr Bertrand Collet

Institution: 

  • Marine Scotland Science
  • Pilot study grant

Attention Bias: A novel method to assess psychological well-being in group-housed non-human primates.

Principal Investigator: 

  • Dr Emily Bethell

Institution: 

  • Liverpool John Moores University
  • Pilot study grant

Finding effective analgesics in zebrafish by analysing effects on the nervous system (CNS)

Principal Investigator: 

  • Professor Catherina Becker

Institution: 

  • University of Edinburgh
  • Pilot study grant

Signalling pathways of leukocyte migration in silico

Principal Investigator: 

  • Dr Juliane Liepe

Institution: 

  • Imperial College London
  • Fellowship

Development of a sensitive in vitro system for anti-alpha-synuclein aggregation drug screening

Principal Investigator: 

  • Dr Maria Eugenia Herva Moyano

Institution: 

  • University of Cambridge
  • Fellowship

Development of an in vitro culture system generating haematopoietic dendritic cells (DCs) from mouse embryonic stem cells

Principal Investigator: 

  • Dr Pierre Guermonprez

Institution: 

  • King's College London
  • PhD Studentship

Development of urinary exosomes as biomarkers of drug-induced kidney injury

Principal Investigator: 

  • Dr James Dear

Institution: 

  • University of Edinburgh
  • PhD Studentship

Refining an established model of hypertension in the mouse

Principal Investigator: 

  • Professor Susan Brain

Institution: 

  • King's College London
  • PhD Studentship

Development of an in vitro system to determine the causes of aberrant, leukaemogenic V(D)J recombination reactions

Principal Investigator: 

  • Dr Joan Boyes

Institution: 

  • University of Leeds
  • PhD Studentship

Using molecular simulation to improve prediction of drug export

Principal Investigator: 

  • Dr Philip Biggin

Institution: 

  • University of Oxford
  • PhD Studentship

Bone healing and regeneration in an ex vivo bioreactor – evaluation of angiogenesis and reparation for clinical application

Principal Investigator: 

  • Professor Richard Oreffo

Institution: 

  • University of Southampton
  • PhD Studentship

Developing a novel model to assess the specificity of appetite-reducing agents

Principal Investigator: 

  • Dr Kevin Murphy

Institution: 

  • Imperial College London
  • PhD Studentship

Construction of a miniaturised human lymph node model as an alternative to the Local Lymph Node Assay

Principal Investigator: 

  • Professor Amir Ghaemmaghami

Institution: 

  • University of Nottingham
  • PhD Studentship

Investigating tuberculosis by engineering human granulomas

Principal Investigator: 

  • Dr Liku Tezera

Institution: 

  • University of Southampton
  • Pilot study grant

Training and teaching resources to underpin implementation of refinement of in vivo studies

Principal Investigator: 

  • Professor Paul Flecknell

Institution: 

  • Newcastle University
  • Infrastructure grant

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