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3D hiPSC derived skin model and in-silico skin modelling of metabolism

  • CRACK IT Challenge

A human IPS cell model for gene therapy vector safety evaluation

  • CRACK IT Challenge

A Brave New Homecage

  • CRACK IT Challenge

Rodent Big Brother

  • CRACK IT Solution

Portable bioluminescence test for botulinum neurotoxin

  • CRACK IT Solution

Review of the use of two species in regulatory toxicology studies

  • Office-led project

Automated predictive welfare assessment in groups of fish

Institution: 

  • University of Lincoln
  • Project grant

Towards in vitro oncology trials: drug testing in cultured patient derived tumour organoid cultures

Institution: 

  • King's College London
  • Project grant

Developing a zebrafish model of neurovascular coupling (NVC)

Institution: 

  • University of Sheffield
  • Project grant

A 3D in vitro glioblastoma cell culture system for identification and evaluation of novel radiosensitisers reducing rodent xenograft studies

Institution: 

  • University of Glasgow
  • Project grant

Unravelling the mechanism of transcellular chaperone signalling in C. elegans

Institution: 

  • University of Leeds
  • Project grant

Developing alternative models to evaluate the impact of nanomaterials on neutrophils during the stimulation and resolution of inflammation

Institution: 

  • Heriot-Watt University
  • Project grant

Assessing the predictive value of safety pharmacology studies

  • Office-led project

Reducing the use and refining the distribution of male Xenopus

Institution: 

  • University of Portsmouth
  • Infrastructure grant

Human tissue models for lung disease

Institution: 

  • Imperial College London
  • Infrastructure grant

In silico human-based methodologies for evaluation of drug cardiac safety and efficacy

Institution: 

  • University of Oxford
  • Infrastructure grant

Affimers: animal free alternatives to antibodies

  • CRACK IT Solution

A novel product for reducing animal numbers in the production of transgenic mice

  • CRACK IT Solution

ZeGlobalTox: multi-organ toxicity testing in zebrafish

  • CRACK IT Solution

Origin retinas syringe insertion device

  • CRACK IT Challenge

NephroScreen: toxicity screening with a human renal cell line in a perfused titerplate

  • CRACK IT Challenge

A miniature wireless EEG system for continuous monitoring of mice brainwave activity

  • CRACK IT Challenge

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