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Pharmaceuticals and chemicals
Displaying 1 - 25 of 113
Sharp and to the Point: Developing a device for injections in mice that avoids the re-use of needles
CRACK IT Challenge
AstraZeneca
Development of non-mammalian, preclinical screening tools for the predictive analysis of cardiotoxicity
PhD Studentship
University of East Anglia
Direct replacement of secondary antibodies by Affimer proteins
PhD Studentship
University of Leeds
Validating CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes as tools to assist with toxicity profiling, adverse drug reaction notices and black box warnings
Technologies to Tools grant
University of Nottingham
Developing a rapid method for identification of key proteins that define tissues to create an array of tissue-specific hydrogels for human-relevant in vitro 3D culture
Technologies to Tools grant
University of Nottingham
Application of non-animal approaches for decision-making in chemical safety assessment
Office-led project
DARTpaths: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects
CRACK IT Challenge
Shell
Validating CombiDART in the agrochemical sector
CRACK IT Solution
Syngenta
A highly sensitive replacement assay for botulinum neurotoxin type B
Project grant
University of Sheffield
RespiraTox: In silico model for predicting human respiratory irritation
CRACK IT Challenge
University of Birmingham
Shell
A new sensor platform combining plastic antibodies with simple thermal detection
CRACK IT Solution
MIP Diagnostics Limited
Moving the Adverse Outcome Pathways Framework towards Practical Utility by Integrating Compound Profiling Data and Using Deep Learning
PhD Studentship
University of Cambridge
Validating the cross-species comparative in silico platform (CRISP)
CRACK IT Solution
Dow AgroSciences
3D hiPSC derived laminated retinal model as a tool for toxicology studies
CRACK IT Challenge
Newcastle University
Merck
Development of an AOP for cardiotoxicity mediated by the blockade of L-type calcium channel
Strategic grant
Brunel University
Human Tissue for Safety Pharmacology
Office-led project
Using chicken eggs to advance the 3Rs in cancer drug discovery
CRACK IT Solution
Design, Fabrication and Testing of a Mouse Embryo Culture Chip
CRACK IT Challenge
MRC Harwell
Chair restraint training of non-human primates
Office-led project
Integrated web platform for agro-chemical formulation toxicity classification and data sharing
CRACK IT Challenge
University of York
Dow AgroSciences and Syngenta
Non-invasive in vivo tissue imaging with functional optical coherence tomography (OCT)
CRACK IT Solution
University of Washington
Applying exposure science to increase the utility of non-animal data in efficacy and safety testing
Office-led project
Opportunities to apply the 3Rs in the safety assessment of nanomaterials
Office-led project
Maximising the success of bile duct cannulation studies
Office-led project
TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Demuris)
CRACK IT Solution
Demuris

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