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Using C. elegans to produce proteins from parasitic nematodes for research and therapeutic use

Principal Investigator: 

  • Dr David Weinkove

Institution: 

  • Durham University
  • Pilot study grant

Single dose acute toxicity studies

  • Office-led project

Replacement of murine transplantation assays by 3D in vitro substitutes for the assessment of therapeutic responses of cancer stem cells.

Principal Investigator: 

  • Professor Ian MacKenzie

Institution: 

  • Queen Mary University of London
  • Project grant

Establishment of non-transformed, continuously growing, alternatively activated mouse macrophage cell lines

Principal Investigator: 

  • Dr Gyorgy Fejer

Institution: 

  • University of Southampton
  • Pilot study grant

Development of an in vitro screening system to minimise animal use in the search for factors that modulate (re)myelination

Institution: 

  • University of Glasgow
  • Pilot study grant

Towards an in vitro system of predictive biomarkers of in vivo liposome efficacy

Principal Investigator: 

  • Dr Andrew Devitt

Institution: 

  • Aston University
  • Pilot study grant

Novel approaches to immortalise salmon fish cells

Principal Investigator: 

  • Dr Bertrand Collet

Institution: 

  • Marine Scotland Science
  • Pilot study grant

Signalling pathways of leukocyte migration in silico

Principal Investigator: 

  • Dr Juliane Liepe

Institution: 

  • Imperial College London
  • Fellowship

Development of a sensitive in vitro system for anti-alpha-synuclein aggregation drug screening

Principal Investigator: 

  • Dr Maria Eugenia Herva Moyano

Institution: 

  • University of Cambridge
  • Fellowship

Development of an in vitro culture system generating haematopoietic dendritic cells (DCs) from mouse embryonic stem cells

Principal Investigator: 

  • Dr Pierre Guermonprez

Institution: 

  • King's College London
  • PhD Studentship

Development of an in vitro system to determine the causes of aberrant, leukaemogenic V(D)J recombination reactions

Principal Investigator: 

  • Dr Joan Boyes

Institution: 

  • University of Leeds
  • PhD Studentship

Using molecular simulation to improve prediction of drug export

Principal Investigator: 

  • Dr Philip Biggin

Institution: 

  • University of Oxford
  • PhD Studentship

Bone healing and regeneration in an ex vivo bioreactor – evaluation of angiogenesis and reparation for clinical application

Principal Investigator: 

  • Professor Richard Oreffo

Institution: 

  • University of Southampton
  • PhD Studentship

Construction of a miniaturised human lymph node model as an alternative to the Local Lymph Node Assay

Principal Investigator: 

  • Professor Amir Ghaemmaghami

Institution: 

  • University of Nottingham
  • PhD Studentship

Investigating tuberculosis by engineering human granulomas

Principal Investigator: 

  • Dr Liku Tezera

Institution: 

  • University of Southampton
  • Pilot study grant

Reducing and replacing mouse use to model the human platelet response in vivo

Institution: 

  • Imperial College London
  • Project grant

Replacement in vitro assays for the quantification of clostridial vaccine antigens

  • Project grant

An ex vivo mouse mandible culture model to study inflammatory bone disease

Principal Investigator: 

  • Professor Alastair Sloan

Institution: 

  • Cardiff University
  • Project grant

Embryonic stem cell-derived cardiomyocytes as a model system for cardiac investigations

Principal Investigator: 

  • Professor Sian Harding

Institution: 

  • Imperial College London
  • Project grant

Development of an air-interface in vitro organ culture model (IVOC) of bovine respiratory epithelium

Principal Investigator: 

  • Dr Alexander W Tucker

Institution: 

  • University of Cambridge
  • Project grant

Maintenance of Lutzomyia longipalpis colonies using an artificial membrane blood-feeding method

Principal Investigator: 

  • Professor Richard Ward

Institution: 

  • Keele University
  • Project grant

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