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An industrial standard cancer drug development platform using human induced pluripotent stem cell technology

Institution: 

  • Newcastle University
  • Fellowship

Intestinal organoids as a replacement strategy to unravel early host intestinal epithelia interactions with whipworms

Institution: 

  • Wellcome Trust Sanger Institute
  • Fellowship

The establishment of left-right asymmetry in mammalian development

Institution: 

  • University of Liverpool
  • Fellowship

Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts

Institution: 

  • University of Nottingham
  • PhD Studentship

Investigation of key inflammatory cells & mediators in zebrafish larval tailfin & heart repair/regeneration following resolution of inflammation

Institution: 

  • University of Edinburgh
  • PhD Studentship

In silico design and optimisation of novel host-directed therapies

Institution: 

  • Imperial College London
  • PhD Studentship

Identifying regulators of tissue regeneration by in vivo imaging in the zebrafish

Institution: 

  • King's College London
  • PhD Studentship

Genetic screens in intestinal/colon organoid (mini-gut) culture using the CRISPR-Cas9 system

Institution: 

  • University of Nottingham
  • PhD Studentship

Organoid and single cell models of bladder cancer

Institution: 

  • University of Leeds
  • PhD Studentship

Standardisation of preclinical PET/CT protocols across multiple research centres

Institution: 

  • University of Edinburgh
  • PhD Studentship

In vitro reconstitution of the polymicrobial community associated with cystic fibrosis airway infections

Institution: 

  • University of Cambridge
  • PhD Studentship

3D hiPSC derived skin model and in-silico skin modelling of metabolism

  • CRACK IT Challenge

A human IPS cell model for gene therapy vector safety evaluation

  • CRACK IT Challenge

Portable bioluminescence test for botulinum neurotoxin

  • CRACK IT Solution

Towards in vitro oncology trials: drug testing in cultured patient derived tumour organoid cultures

Institution: 

  • King's College London
  • Project grant

Developing a zebrafish model of neurovascular coupling (NVC)

Institution: 

  • University of Sheffield
  • Project grant

A 3D in vitro glioblastoma cell culture system for identification and evaluation of novel radiosensitisers reducing rodent xenograft studies

Institution: 

  • University of Glasgow
  • Project grant

Unravelling the mechanism of transcellular chaperone signalling in C. elegans

Institution: 

  • University of Leeds
  • Project grant

Developing alternative models to evaluate the impact of nanomaterials on neutrophils during the stimulation and resolution of inflammation

Institution: 

  • Heriot-Watt University
  • Project grant

Human tissue models for lung disease

Institution: 

  • Imperial College London
  • Infrastructure grant

In silico human-based methodologies for evaluation of drug cardiac safety and efficacy

Institution: 

  • University of Oxford
  • Infrastructure grant

Affimers: animal free alternatives to antibodies

  • CRACK IT Solution

A novel product for reducing animal numbers in the production of transgenic mice

  • CRACK IT Solution

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