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Developing and validating an in vitro mycobacterial challenge model to facilitate TB vaccine research and minimise in vivo challenge

Institution: 

  • University of Oxford
  • Strategic grant

A bovine alveolus model to replace cattle in the study of host-pathogen interactions in bovine tuberculosis

Institution: 

  • University of Surrey
  • Strategic grant

An integrative Dictyostelium, C. elegans and zebrafish approach to assess DART

  • CRACK IT Challenge

Utilising QSARs to predict fish acute toxicity of pesticide metabolites

  • Office-led project

Probing in vivo parasite biology in vitro

Institution: 

  • Queen's University Belfast
  • Project grant

Human stem cell derived neurones and astrocytes as an in vitro model of human prion infection and replication

Institution: 

  • University of Edinburgh
  • Project grant

Modelling liver fibrosis using human Induced Pluripotent Stem Cells

Institution: 

  • University of Cambridge
  • Project grant

Development of a tetanus-sensitive cell line for assaying tetanus toxin activity

Institution: 

  • University of Sheffield
  • Project grant

A multi-cellular 3D model of human breast tissue to replace rodent xenograft models in breast cancer research

Institution: 

  • University of Nottingham
  • Project grant

Advancing the development and application of non-animal technologies (NATs)

  • Office-led project

Replacing, reducing and refining the use of animals in anti-filarial drug testing

Principal Investigator: 

  • Dr Joseph Turner

Institution: 

  • Liverpool School of Tropical Medicine
  • PhD Studentship

A non-mammalian model for neurofunctional studies of vertebrate dopamine signalling

Principal Investigator: 

  • Dr Jonathan McDearmid

Institution: 

  • University of Leicester
  • PhD Studentship

An organotypic model of bronchial dysplasia

Institution: 

  • University of Cambridge
  • PhD Studentship

C. elegans model to unravel the role of Klotho in ion metabolism and ageing

Principal Investigator: 

  • Dr Tarja Kinnunen

Institution: 

  • University of Huddersfield
  • PhD Studentship

An ovarian cancer model on a chip

Principal Investigator: 

  • Dr Julien Gautrot

Institution: 

  • Queen Mary University of London
  • PhD Studentship

A non-mammalian model to study innate immune modulation of airways remodelling in asthma

Institution: 

  • University of Sheffield
  • Strategic grant

Developing a non-animal model system to investigate bitter tastants as new treatments for asthma

Principal Investigator: 

  • Professor Robin Williams

Institution: 

  • Royal Holloway University of London
  • Strategic grant

Developing a model for the study of respiratory inflammation in the zebrafish

Principal Investigator: 

  • Professor Margaret Dallman

Institution: 

  • Imperial College London
  • Strategic grant

Use of Drosophila models to explore the function of asthma susceptibility genes

Principal Investigator: 

  • Professor Donna Davies

Institution: 

  • University of Southampton
  • Strategic grant

Engineering tissue alternatives to animals

  • Office-led project

Reducing animal use in complex systems: using nausea and vomiting as a test case

  • Office-led project

Applying pathways-based approaches across the biosciences

  • Office-led project

Development of an in vitro model of 'pain'

Principal Investigator: 

  • Dr Ramin Raouf

Institution: 

  • King's College London
  • Project grant

Novel biomarker platform for a 3Rs approach to assessment of developmental and reproductive toxicity

Principal Investigator: 

  • Dr Catherine Pears

Institution: 

  • University of Oxford
  • Project grant

Mechanisms of intestinal epithelial responses to inflammatory modulators

Principal Investigator: 

  • Professor Inke Nathke

Institution: 

  • University of Dundee
  • Project grant

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