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Using chicken eggs to advance the 3Rs in cancer drug discovery

  • CRACK IT Solution

Opportunities to apply the 3Rs in the safety assessment of nanomaterials

  • Office-led project

Maximising the success of bile duct cannulation studies

  • Office-led project

Review of the use of two species in regulatory toxicology studies

  • Office-led project

Improving the predictive capacity of in vitro cytokine release assays to reduce animal use and drug attrition

  • CRACK IT Challenge

Review of global data requirements for plant protection products

  • Office-led project

Reducing repetition of regulatory vertebrate ecotoxicology studies

  • Office-led project

Utilising QSARs to predict fish acute toxicity of pesticide metabolites

  • Office-led project

Applying the one concentration approach in fish bioaccumulation studies

  • Office-led project

Applying the threshold approach in fish acute toxicity studies

  • Office-led project

Assessing the need for chronic fish studies on formulated pesticides

  • Office-led project

Humane endpoints for rodenticide testing

Principal Investigator: 

  • Dr Alan MacNicoll

Institution: 

  • Department for Environment
  • Food & Rural Affairs (Defra)
  • Project grant

Applying pathways-based approaches across the biosciences

  • Office-led project

Toxicokinetics in the chemicals industry

  • Office-led project

In vitro approaches for carcinogenicity testing

  • Office-led project

Development of a non-mammalian, pre-clinical screening tool (FETOX) for predictive analysis of drug safety

Principal Investigator: 

  • Dr Grant Wheeler

Institution: 

  • University of East Anglia
  • PhD Studentship

Development of urinary exosomes as biomarkers of drug-induced kidney injury

Principal Investigator: 

  • Dr James Dear

Institution: 

  • University of Edinburgh
  • PhD Studentship