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Development of an in vitro system to determine the causes of aberrant, leukaemogenic V(D)J recombination reactions

Principal Investigator: 

  • Dr Joan Boyes

Institution: 

  • University of Leeds
  • PhD Studentship

Using molecular simulation to improve prediction of drug export

Principal Investigator: 

  • Dr Philip Biggin

Institution: 

  • University of Oxford
  • PhD Studentship

Bone healing and regeneration in an ex vivo bioreactor – evaluation of angiogenesis and reparation for clinical application

Principal Investigator: 

  • Professor Richard Oreffo

Institution: 

  • University of Southampton
  • PhD Studentship

Developing a novel model to assess the specificity of appetite-reducing agents

Principal Investigator: 

  • Dr Kevin Murphy

Institution: 

  • Imperial College London
  • PhD Studentship

Construction of a miniaturised human lymph node model as an alternative to the Local Lymph Node Assay

Principal Investigator: 

  • Professor Amir Ghaemmaghami

Institution: 

  • University of Nottingham
  • PhD Studentship

Investigating tuberculosis by engineering human granulomas

Principal Investigator: 

  • Dr Liku Tezera

Institution: 

  • University of Southampton
  • Pilot study grant

Training and teaching resources to underpin implementation of refinement of in vivo studies

Principal Investigator: 

  • Professor Paul Flecknell

Institution: 

  • Newcastle University
  • Infrastructure grant

Development of non-radioactive labels for a receptor binding assay for paralytic shellfish poisoning (PSP) toxin testing

Principal Investigator: 

  • Professor Christopher Elliott

Institution: 

  • Queen's University Belfast
  • PhD Studentship

Reduction and refinement of murine models of bacterial infection

Principal Investigator: 

  • Professor Shiranee Sriskandan

Institution: 

  • Imperial College London
  • Project grant

Neonatal BCG vaccination: screening for genetic factors that influence host-pathogen interactions and reducing and replacing the requirement for animal infection models in immune mechanism discovery

Principal Investigator: 

  • Professor Melanie Newport

Institution: 

  • Brighton and Sussex Medical School
  • PhD Studentship

Optimisation of a flow-based human in vitro blood–brain barrier model to replace animal models for studying immunopathogenesis of viral brain infections

Principal Investigator: 

  • Dr Adjanie Patabendige

Institution: 

  • University of Liverpool
  • Fellowship

Reducing and replacing mouse use to model the human platelet response in vivo

Principal Investigator: 

  • Dr Michael Emerson

Institution: 

  • Imperial College London
  • Project grant

Replacement in vitro assays for the quantification of clostridial vaccine antigens

Principal Investigator: 

  • Dr Keith Redhead
  • Project grant

The development of an in vitro model of central nervous system injury to identify factors which promote repair

Principal Investigator: 

  • Professor Susan Barnett

Institution: 

  • Unversity of Glasgow
  • Project grant

An ex vivo mouse mandible culture model to study inflammatory bone disease

Principal Investigator: 

  • Professor Alastair Sloan

Institution: 

  • Cardiff University
  • Project grant

Embryonic stem cell-derived cardiomyocytes as a model system for cardiac investigations

Principal Investigator: 

  • Professor Sian Harding

Institution: 

  • Imperial College London
  • Project grant

Refinement of a mouse model of pulmonary embolism

Principal Investigator: 

  • Dr Michael Emerson

Institution: 

  • Imperial College London
  • Project grant

Development of a new tissue-friendly head implant for use in awake, behaving monkey studies

Principal Investigator: 

  • Professor Roger Lemon

Institution: 

  • University College London
  • Project grant

Development of an air-interface in vitro organ culture model (IVOC) of bovine respiratory epithelium

Principal Investigator: 

  • Dr Alexander W Tucker

Institution: 

  • University of Cambridge
  • Project grant

Maintenance of Lutzomyia longipalpis colonies using an artificial membrane blood-feeding method

Principal Investigator: 

  • Professor Richard Ward

Institution: 

  • Keele University
  • Project grant

The behaviour of laboratory mice as an indicator of welfare state in genetically modified mice

Principal Investigator: 

  • Professor Christine Nicol

Institution: 

  • University of Bristol
  • Project grant

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