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Replacing, refining and reducing animal usage in epilepsy research using a non-sentient model

Principal Investigator: 

  • Professor Robin Williams

Institution: 

  • Royal Holloway University of London
  • Project grant

Asthma models

  • Office-led project

Replacing rodent models for investigating the influence of the microbiome upon innate immune responses and resistance to pathogens

Principal Investigator: 

  • Dr Rachel Lawrence

Institution: 

  • Royal Veterinary College
  • PhD Studentship

An in vitro model to investigate the role of oestrogen and oestrogen metabolism in pulmonary vascular disease

Principal Investigator: 

  • Professor Margaret MacLean

Institution: 

  • University of Glasgow
  • PhD Studentship

Multi-user, multi-centre MRI to reduce and refine the use of mice in cancer and trauma research

Principal Investigator: 

  • Dr John Marshall

Institution: 

  • Queen Mary University of London
  • Infrastructure grant

Applying the 3Rs to elucidate the mechanisms of tau pathology using DRG neurons in culture

Principal Investigator: 

  • Professor Maria Grazia Spillantini

Institution: 

  • University of Cambridge
  • Project grant

A 3D air-liquid interface airway epithelial cell model to study pathogen interactions within the bovine respiratory tract

Principal Investigator: 

  • Dr Robert Davies

Institution: 

  • University of Glasgow
  • Project grant

3D gene knockout tissue models using adult human stem cells

Principal Investigator: 

  • Professor Paul Genever

Institution: 

  • University of York
  • PhD Studentship

Toxicokinetics in the chemicals industry

  • Office-led project

Impact of rodent age on study outcome

  • Office-led project

Pharmacokinetics in candidate selection

  • Office-led project

Abuse potential studies

  • Office-led project

Reducing the use of recovery animals

  • Office-led project

Reducing animal use in monoclonal antibody development

  • Office-led project

Refining MTD studies

  • Office-led project

The Experimental Design Assistant - EDA

  • Office-led project

NC3Rs/NIH OLAW Experimental design and reporting survey

  • Office-led project

Refining the use of chronic implants in non-human primate neuroscience

  • Office-led project

ARRIVE: Animal Research Reporting In Vivo Experiments

  • Office-led project

In vitro approaches for carcinogenicity testing

  • Office-led project

The snail assay as an alternative to the rodent Hershberger assay for detecting androgens and anti-androgens

Principal Investigator: 

  • Dr Susan Jobling

Institution: 

  • Brunel University
  • Project grant

A chronic model of epilepsy in organotypic brain slice cultures of the rat entorhinal cortex

Principal Investigator: 

  • Professor Roland Jones

Institution: 

  • University of Bath
  • Project grant

Development of cell based assays as replacement assays for Botulinum toxins and antitoxins

Principal Investigator: 

  • Dr Dorothea Sesardic

Institution: 

  • National Institute for Biological Standards and Control
  • Project grant

A tissue engineered construct to monitor mucosal immunity in asthma

Principal Investigator: 

  • Professor Donna Davies

Institution: 

  • University of Southampton
  • Strategic grant

Developing a platform of in vitro models of asthmatic and healthy lung: an alternative to the use of animals in asthma research

Principal Investigator: 

  • Dr Felicity Rose

Institution: 

  • University of Nottingham
  • Strategic grant

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