Application of non-animal approaches for decision-making in chemical safety assessment
Current contact:
Dr Fiona Sewell
- Office-led project
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DARTpaths: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects
Contractor:
Professor Raymond Pieters, University of Applied Sciences Utrecht (UASU)
- CRACK IT Challenge
Acoustic Vocalisation Early Response Technologies (AVERT)
Principal Investigator:
Dr Liane Hobson
Institution:
- MRC Harwell
- Fellowship
Focused molecular understanding of hypertrophic cardiomyopathy using CRISPR-engineered human pluripotent stem cell-derived cardiomyocytes
Principal Investigator:
Dr Diogo Mosqueira
Institution:
- University of Nottingham
- Fellowship
From ageing to space travel: Developing an organotypic model of skeletal tissue disuse for understanding degeneration in altered environments
Principal Investigator:
Dr Alexandra Iordachescu
Institution:
- University of Birmingham
- Fellowship
Refining the lung cancer mouse model through environmental enrichment
Principal Investigator:
Dr Deborah Caswell
Institution:
- The Francis Crick Institute
- Fellowship
Development of an invertebrate model of alternating hemiplegia of childhood
Principal Investigator:
Dr Steven Clapcote
Institution:
- University of Leeds
- PhD Studentship
Experimental evolution of Pseudomonas aeruginosa in media replicating the conditions of the upper and lower airways
Principal Investigator:
Dr Daniel Neill
Institution:
- University of Liverpool
- PhD Studentship
Fasting-induced torpor in mice: effects on sleep and behaviour
Principal Investigator:
Professor Vladyslav Vyazovskiy
Institution:
- University of Oxford
- PhD Studentship
Development and characterization of a novel endothelialized in vitro model of human atherothrombosis
Principal Investigator:
Dr Sarah Jones
Institution:
- Manchester Metropolitan University
- PhD Studentship
An organotypic model of the bone remodelling process
Principal Investigator:
Dr Amy Naylor
Institution:
- University of Birmingham
- PhD Studentship
A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic model
Principal Investigator:
Dr Adrian Biddle
Institution:
- Queen Mary University of London
- PhD Studentship
Modelling Candida albicans infection of the human gut using human intestinal organoid cultures
Principal Investigator:
Dr Silvia Gratz
Institution:
- University of Aberdeen
- PhD Studentship
Refining weaning age in macaques destined for neuroscience research
Principal Investigator:
Professor Melissa Bateson
Institution:
- Newcastle University
- PhD Studentship
Maternal immune activation: advancing from rodents to humans through a development of a hIPSC model to study gene x environment interactions
Principal Investigator:
Dr Anthony Vernon
Institution:
- King's College London
- PhD Studentship
Development of novel models of kidney damage using induced human pluripotent stem cells
Principal Investigator:
Dr Derek Brazil
Institution:
- Queen's University Belfast
- PhD Studentship
Fusogenic liposomes: the innovative delivery of compounds into human platelets to reduce animal use in platelet research
Principal Investigator:
Dr Alice Pollitt
Institution:
- University of Reading
- PhD Studentship
An in vivo genetic screen of lung function candidate genes using tissue specific RNAi in Drosophila melanogaster
Principal Investigator:
Dr Marios Georgiou
Institution:
- University of Nottingham
- PhD Studentship
Reducing number of mice required for drug testing via development of first in vitro automated screening platform of injured mammalian brain
Principal Investigator:
Dr Veronique Miron
Institution:
- University of Edinburgh
- PhD Studentship
Advanced in vitro and in silico models to predict and prevent deep venous thrombosis
Principal Investigator:
Dr Alessio Alexiadis
Institution:
- University of Birmingham
- PhD Studentship
Replacement of animal models of cardiac arrest and resuscitation strategies using a computer simulation
Principal Investigator:
Professor Jonathan Hardman
Institution:
- University of Nottingham
- PhD Studentship
Replacing Alzheimer's disease (AD) - Down syndrome (DS) mice with fly models
Principal Investigator:
Dr Frances Wiseman
Institution:
- University College London
- PhD Studentship
Towards multiplexed in vivo phenotypic screening to improve antimicrobial drug discovery
Principal Investigator:
Dr Matthew Child
Institution:
- Imperial College London
- PhD Studentship
Validating CombiDART in the agrochemical sector
Contractor:
Professor Alison Woollard
- CRACK IT Solution