In vitro cross species renal proximal tubule

Dr Colin Brown (Newcastle University and Abcellute) has developed primary cultures of proximal tubule cells grown as monolayers on permeable filter supports (aProximate™). These renal models remain differentiated, allowing both a mechanistic and predictive understanding of drug transporters and drug-drug interactions. Identifying compounds destined to fail in humans due to nephrotoxicity early in the drug discovery process using more predictive in vitro assays will avoid drugs destined to fail in development being tested in animals. Collaborations are sought in the pharmaceutical or biotechnology sector to develop and validate primary cell cultures for inter-species comparisons of renal toxicity. For further information please see the flyer.

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