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NC3Rs | 20 Years: Pioneering Better Science
Pioneering better science

Replacement, Reduction and Refinement

A UK-based scientific organisation dedicated to helping the research community worldwide to identify, develop and use 3Rs technologies and approaches.
Our mission
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Guidelines, practical information, publications, video and training materials to help you put the 3Rs into practice.

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We fund world class researchers to develop predictive, reliable and humane 3Rs approaches.

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Details of NC3Rs projects, including grants, early career awards and work led by our staff.

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What are the 3Rs? How many animals are used in research? Find answers to these questions and more.

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Latest news

The ARRIVE study plan is a freely available resource to assess the rigour and improve the transparency of planned animal research.

The ARRIVE study plan

Our total commitment for project grants over the past twenty years has now surpassed £50M, supporting 3Rs method development, characterisation and dissemination.

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CRACK IT

Discover 3Rs innovations from the NC3Rs

Bringing together expertise from different sectors and disciplines to deliver readily available and easily deployed 3Rs models and tools that are more predictive and cost-effective than current animal models.

Discover our CRACK IT Challenges funding competition
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