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NC3Rs | 20 Years: Pioneering Better Science
Pioneering better science

Replacement, Reduction and Refinement

A UK-based scientific organisation dedicated to helping the research community worldwide to identify, develop and use 3Rs technologies and approaches.
Our mission
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Guidelines, practical information, publications, video and training materials to help you put the 3Rs into practice.

Black mouse sitting on open hands. The technician is wearing a blue coveralls and blue medical grade gloves.

We fund world class researchers to develop predictive, reliable and humane 3Rs approaches.

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Details of NC3Rs projects, including grants, early career awards and work led by our staff.

Two researchers look at a sample in a Petri dish

What are the 3Rs? How many animals are used in research? Find answers to these questions and more.

Two white rats in an enriched cage containing cardboard tunnels and paper towels.

Latest news

Our total commitment for project grants over the past twenty years has now surpassed £50M, supporting 3Rs method development, characterisation and dissemination.

Centrifuge tubes in a orange rack

Our Experimental Design Assistant (EDA) helps you to design robust and meaningful animal experiments. With a wealth of information, features and tools, here are our tips to help you make the most of the EDA.

A diagram showing how the EDA can be used to represent a two group comparison experiment. The EDA works by dragging and dropping 'nodes' which appear as coloured shapes. These are then connected with arrows or ‘links’ showing how different parts of an experiment relate to each other. The EDA then uses computer-based logical reasoning to provide feedback on the experimental design.
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CRACK IT

Discover 3Rs innovations from the NC3Rs

Bringing together expertise from different sectors and disciplines to deliver readily available and easily deployed 3Rs models and tools that are more predictive and cost-effective than current animal models.

Discover our CRACK IT Challenges funding competition
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