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£1M awarded to replace animal studies and improve the safety assessment of cell therapies A team led by Professor Toni Cathomen at the University of Freiburg (Germany) has secured £1M of CRACK IT Challenge funding to develop an approach to evaluate the tumourigenicity of human engineered T cell therapies. 24 January 2024
Sponsor a Challenge: overcome scientific barriers with 3Rs-driven solutions Sponsor a Challenge: overcome scientific barriers with 3Rs-driven solutions. We are looking for stakeholders from across the biosciences to submit their ideas for new CRACK IT Challenges. 08 December 2023
Call open for 2024 CRACK IT Challenges We are looking for experts with research questions that could be solved with a 3Rs driven approach. 23 November 2023
2023 CRACK IT Challenges open for applications The 2023 CRACK IT Challenges Competition is now open - Invitation to Tender 08 September 2023
£4M funding available to solve the 2023 CRACK IT Challenges Open for applications: four new Challenges have been announced in this year’s open innovation funding competition. 01 August 2023
£100k awarded to develop an in silico tool to predict thyroid receptor-mediated endocrine disruption Funding for 18 months has been awarded to a team at KREATiS to deliver the CRACK IT Challenge Thyroid Tox. 29 March 2023
£1.6M awarded for Phase 2 of the 2021 Virtual Second Species Mega Challenge esqLABS have been awarded the Phase 2 contract to develop a NAMs-driven in silico framework to predict toxicological endpoints in the dog. 13 March 2023
£200k awarded to deliver Phase 1 of the T-ALERT CRACK IT Challenge 19 January 2023 Two teams have been awarded £100k funding each to carry out Phase 1 proof-of-concept studies to establish an in vitro assay system to evaluate the tumourigenicity of genetically engineered T cell therapies*. 13 January 2023