News | Innovation Platform

Automated monitoring of mouse behaviour in social home cage groups

The development of the home cage monitoring system was funded by the NC3Rs through its open innovation programme CRACK IT Challenges and provides for the first time the kit to automate the recording and analysis of the activity and behaviour of individual mice housed socially in their home cage.

14 June 2016

ZeGlobalTox landscape, much more than a simple Solution

Dr Davide D'Amico, Chief Executive Officer of ZeClinics provides his perspective on the impact of CRACK IT Solutions on the development and application of the ZeGlobalTox technology platform for drug development, and on ZeClinics business more generally.

01 June 2016

New Solution: Cell-based VAMP reporter assay for tetanus vaccine development

Work funded by the NC3Rs at the University of Sheffield has led to the development of a cell-based reporter assay that has the potential to replace thousands of animal tests currently used in the production of tetanus and botulinum vaccines

20 May 2016

New Solution: devTOX: Human Pluripotent Stem Cell-based Developmental Toxicity Assays

Stemina Biomarker Discovery, Inc. has developed two reliable human stem cell-based assays for developmental toxicity screening.

devTOX quickPredict rapidly predicts the developmental toxicity potential of test articles with 89% accuracy (79% sensitivity, 100% specificity), while devTOX Discovery identifies changes in secreted metabolites to help identify mechanisms of toxicity. Both are available using human embryonic stem (hES) and induced pluripotent stem (iPS) cells.

19 May 2016

New Solution: Human tissue-on-a-chip: a personalised response is possible

Work funded by the NC3Rs at the University of Hull has led to the development of microfluidic devices capable of maintaining architecture, physiology and function of human tissue ex vivo.

21 April 2016

New Solution: TruLarv Galleria mellonella- a model host for infection studies, toxicity testing and drug development

Biosystems Technologies Ltd. have developed TruLarvTM, research grade Galleria mellonella larvae for use in chemical and drug development pipelines as early screens for assessing efficacy and toxicity.

18 April 2016

Increasing the relevance of in vitro hepatocyte models for liver toxicity testing

A new study has shown that introducing physiologic cues to the in vitro culture of hepatocyte-like cells (HLCs) makes them a more relevant hepatocyte model that can be used in non-animal liver toxicity testing.

23 March 2016

New CRACK IT Solutions funded for collaborations in 3Rs technology development

Three projects have each been awarded £30,000 seed funding, through the NC3Rs CRACK IT Solutions partnering programme, to support collaborations which will help develop, validate and test technologies with 3Rs potential.

09 March 2016