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Increasing the relevance of in vitro hepatocyte models for liver toxicity testing

A new study has shown that introducing physiologic cues to the in vitro culture of hepatocyte-like cells (HLCs) makes them a more relevant hepatocyte model that can be used in non-animal liver toxicity testing. The paper, published last week in Archives of Toxicology, is the result of a collaboration between the University of Edinburgh and biotechnology company Kirkstall Limited, as part of the NC3Rs CRACK IT Solutions technology partnering programme.

23 March 2016
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New CRACK IT Solutions funded for collaborations in 3Rs technology development

Three projects have each been awarded £30,000 seed funding, through the NC3Rs CRACK IT Solutions partnering programme, to support collaborations which will help develop, validate and test technologies with 3Rs potential. The programme links technology developers with researchers and organisations that can add value to the existing “know-how” and ultimately maximise the scientific, commercial and 3Rs opportunities.

Improving the efficiency of genetically engineered mouse breeding programmes

09 March 2016
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Latest CRACK IT Challenges: funding innovative technologies with 3Rs benefits and business potential

Six teams have been awarded funding in Phase 1 of the latest NC3Rs CRACK IT Challenges competition, a challenge-led competition run in collaboration with the UK’s innovation agency, Innovate UK, using its Small Business Research Initiative (SBRI).

CRACK IT Challenges bring together industry, academia and SMEs to tackle current business and scientific questions that have the potential to deliver commercial benefits and reduce the reliance on animals in research.

29 February 2016