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CRACK IT Challenges
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A device to accurately measure individual food intake in group-housed mice.
A handheld device for objective monitoring of rheumatoid arthritis (RA) progression in awake rodents.
An immunologically-competent in vitro model of the human liver for the assessment of Yellow Fever (YF) vaccine attenuation.
An in silico QSAR-based tool that reliably predicts the human respiratory irritancy potential of chemicals.
Improved tools to better quantify and control the exposure of chemicals over a wide range of in vitro assay systems.
Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects.
An in silico model to classify agrochemical mixtures to fulfil acute GHS Classification and Labelling requirements for acute oral toxicity, skin and eye irritation.
An approach that improves the implantation rates of early stage embryos when combined with extended in vitro culture and non-surgical embryo transfer techniques in the generation of transgenic mice.
An in vitro 3D retinal cell model which is physiologically-competent and predictive of human physiology for use in the development of new ophthalmology treatments.
A human cell based in vitro model to recapitulate the human osteoarthritic joint for research and drug development in OA.
A suite of in vitro / in silico assays that can be used to improve risk assessment for gene therapy products.
A model to assess the extent to which skin metabolism determines xenobiotic availability in human skin.
Using existing toxicological data repositories to develop in silico tools to predict toxicological endpoints for substances in order to waive in vivo studies.
Targeting off targets
The development of novel approaches to address the potential human safety issues arising from chemicals interacting with ‘off-target’ receptors.
A physiologically-relevant human stem cell-based model to assess neurotoxicity and seizure liability.
A virtual platform that models infection and the host response to pathogen assault for basic research and enhances new target development in infectious diseases.