Challenges

Group of white mice in a clear cage

Systems to identify individual mice from birth.

Image of zebrafish in a clear tank of water

Development of a fish embryo assay to detect thyroid-active chemicals.

Image of pipette and glass test tubes

Multi-species in vitro developmental toxicity testing.

Organ on a chip image

Real-time multiparametric monitoring of connected organ-on-a-chip devices.

Image of molecules on blue background - Thyroid Tox Challenge

Development of in silico tools to predict endocrine disruption.

Image of T-Cell attacking a cancer cell

In vitro safety assessment of CAR-T cell therapies.

Image of zebrafish in a lab setting

Innovative bioassays for environmental risk assessment and fish toxicity.

Image showing interconnecting lines to form a network.

Virtual Second Species

Development of virtual dog tissues and organs for chronic toxicity studies.

Challenge 39 Tat-Fit

Tasteful tamoxifen for inducible transgenesis.

Challenge 38 Mouse Mapp_image

An application to monitor the welfare of mice.

Challenge 37 STRATIS

A human-relevant and high throughput in vitro or ex vivo platform that recapitulates the complex structures of skeletal muscle and the pathology of significant injury to them.

Challenge 36 Animal Free_image

Animal-free in vitro

Replacement of animal-derived reagents in an established human cell-based in vitro assay associated with an OECD Test Guideline.

Challenge 35 in vitro TDAR

A human immune response assay for the assessment of immune modulation.

Mouse being handled by person with a glove with a yellow background.

Sharp and to the Point

Developing needles for high throughput and critical compound administration in mice.

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Animal free tumourigenicity assessment of genome edited human haematopoietic stem cells.

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Transgene Track

Development of a sensitive, absolute quantification method for tracking AAV gene therapies and CAR-T cells in vivo.