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CRACK IT Challenges
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Tasteful tamoxifen for inducible transgenesis.
An application to monitor the welfare of mice.
A human-relevant and high throughput in vitro or ex vivo platform that recapitulates the complex structures of skeletal muscle and the pathology of significant injury to them.
Animal-free in vitro
Replacement of animal-derived reagents in an established human cell-based in vitro assay associated with an OECD Test Guideline.
In vitro TDAR
A human immune response assay for the assessment of immune modulation
Sharp and to the Point
Developing needles for high throughput and critical compound administration in mice.
Animal free tumourigenicity assessment of genome edited human haematopoietic stem cells.
Development of a sensitive, absolute quantification method for tracking AAV gene therapies and CAR-T cells in vivo.
A device to accurately measure individual food intake in group-housed mice.
A handheld device for objective monitoring of rheumatoid arthritis (RA) progression in awake rodents.
An immunologically-competent in vitro model of the human liver for the assessment of Yellow Fever (YF) vaccine attenuation.
An in silico QSAR-based tool that reliably predicts the human respiratory irritancy potential of chemicals.
Improved tools to better quantify and control the exposure of chemicals over a wide range of in vitro assay systems.
Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects.
An in silico model to classify agrochemical mixtures to fulfil acute GHS Classification and Labelling requirements for acute oral toxicity, skin and eye irritation.
An approach that improves the implantation rates of early stage embryos when combined with extended in vitro culture and non-surgical embryo transfer techniques in the generation of transgenic mice.