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About CRACK IT
CRACK IT Challenges
CRACK IT Solutions
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Targeting off targets
The development of novel approaches to address the potential human safety issues arising from chemicals interacting with ‘off-target’ receptors.
A physiologically-relevant human stem cell-based model to assess neurotoxicity and seizure liability.
A virtual platform that models infection and the host response to pathogen assault for basic research and enhances new target development in infectious diseases.
A multi-compartmental, microfluidic tissue assay that models the renal tubular injury observed in nephrotoxicity.
Longitudinal and non-invasive assessment of inflammation and foamy macrophage toxicity in the same animal through a series of dose-escalation stages.
A physiologically-relevant iPS cell-derived in vitro cardiac contractility platform to assess cardiovascular safety liabilities.
A physiologically relevant human stem cell-derived assay to predict the efficacy and unexpected pharmacological effects of new chemical entities targeting tau in Alzheimer’s disease.
A device to refine intravitreal injection in rabbits to eliminate variations in injection techniques and associated welfare problems.
To develop and characterise non-mammalian assays that can provide an indication of developmental and reproductive toxicity potential to mammals, including man, in order to reduce and refine in vivo mammalian testing.
High quality, viable dorsal root ganglion neurones for researchers to facilitate drug target identification and pharmacological testing of novel pain therapeutics.
A non-invasive imaging modality to define bio distribution of macromolecules in vivo and enable better predictions of efficacy.
Rodent Little Brother
An automated, minimally-invasive system to assess activity, behaviour and interaction for at least two mice in the cages and setting the animals were reared in.
Relevant phenotypical high throughput screens for the discovery of new treatments for bipolar affective disorder (BAD).
A model to provide understanding of the relevance of toxicity data from human in vitro systems to predictions of safety following relevant in vivo human exposure.
To develop in vitro human cell-based models for the testing of antibody-based therapeutics that will allow the prediction of human cytokine release and to develop a parallel assay with cells from non-human primate (e.g. cynomolgus monkey) to predict cytokine release in preclinical safety assessment.
Rodent Big Brother
An automated non-surgical system, which can be used with rats and mice, to measure activity and temperature over a minimum of a 24 hour period.