Challenge 15 NephroTube A multi-compartmental, microfluidic tissue assay that models the renal tubular injury observed in nephrotoxicity.
Challenge 14 Inhalation Translation Longitudinal and non-invasive assessment of inflammation and foamy macrophage toxicity in the same animal through a series of dose-escalation stages.
Challenge 13 InPulse A physiologically-relevant iPS cell-derived in vitro cardiac contractility platform to assess cardiovascular safety liabilities.
Challenge 12 UnTangle A physiologically relevant human stem cell-derived assay to predict the efficacy and unexpected pharmacological effects of new chemical entities targeting tau in Alzheimer’s disease.
Challenge 11 RETINAS A device to refine intravitreal injection in rabbits to eliminate variations in injection techniques and associated welfare problems.
Challenge 10 PREDART To develop and characterise non-mammalian assays that can provide an indication of developmental and reproductive toxicity potential to mammals, including man, in order to reduce and refine in vivo mammalian testing.
Challenge 9 DRGNET High quality, viable dorsal root ganglion neurones for researchers to facilitate drug target identification and pharmacological testing of novel pain therapeutics.
Challenge 8 ProBE IT A non-invasive imaging modality to define bio distribution of macromolecules in vivo and enable better predictions of efficacy.
Challenge 7 Rodent Little Brother An automated, minimally-invasive system to assess activity, behaviour and interaction for at least two mice in the cages and setting the animals were reared in.
Challenge 6 BADIPS Relevant phenotypical high throughput screens for the discovery of new treatments for bipolar affective disorder (BAD).
Challenge 5 IVIVE A model to provide understanding of the relevance of toxicity data from human in vitro systems to predictions of safety following relevant in vivo human exposure.
Challenge 4 Cytokines To develop in vitro human cell-based models for the testing of antibody-based therapeutics that will allow the prediction of human cytokine release and to develop a parallel assay with cells from non-human primate (e.g. cynomolgus monkey) to predict cytokine release in preclinical safety assessment.
Challenge 3 Rodent Big Brother An automated non-surgical system, which can be used with rats and mice, to measure activity and temperature over a minimum of a 24 hour period.
Challenge 2 Cognition A wireless neuronal recording system that acquires and transmits data for a minimum of 24 hours and is small enough to be carried by a mouse without affecting its welfare.
Challenge 1 Nephrotoxicity An in vitro cell-based model for the testing of nephrotoxicity that allows inter-species comparisons between toxicologically relevant species.