NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research
Webinar and video

Welfare webinar: Minimising animal suffering with refined humane endpoints and early interventions

Clearly defined, refined humane endpoints can significantly improve animal welfare without compromising the scientific aims of a study. Humane endpoints and early interventions should be tailored to specific animal models, rather than what is legally permitted across multiple studies.

In this two-part webinar, we were joined by speakers from across sectors to explore how refined, study-specific humane endpoints and early intervention strategies can be implemented in different research scenarios to minimise animal suffering.

A written Q&A will be available soon.

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Speakers and topics

Recordings are available for the following speakers: 

  • Refining bone marrow ablation and reconstitution in mice.
    Penny Hawkins, RSPCA.
  • Snakebite envenoming studies.
    Stuart Ainsworth, University of Liverpool.
  • Humane endpoints, focusing on body weight change as an objective measure of toxicity.
    Mark Blee, Toxicology and Regulatory Sciences team, NC3Rs.
  • Minimising potential suffering in rodent models for pain research.
    Klas Abelson, University of Copenhagen.
  • Severity heat maps: Developing consensus in severity assessment.
    Helen Murphy, GSK.

The live sessions included three additional talks:

  • Managing animal welfare and humane endpoints in preclinical safety studies: Balancing pharmacological activity and scientific endpoints.
    Romalie Allen, Labcorp.
  • Improving in vivo modelling of ischaemic stroke and animal welfare.
    Claire Gibson, University of Nottingham.
  • A comprehensive welfare scoring system for Graft Versus Host Disease clinical assessment in humanised mouse models.
    Alice Nowak, AstraZeneca.

For more information on these topics please contact enquiries@nc3rs.org.uk.

Webinar recording

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