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Welcome to the new NC3Rs site, find out more about the changes and improvements we have made.

NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research

3Rs resource library

Helping you to find information on the 3Rs relevant to your work. Enter a key word below or click view all to see all of the resources available, and apply filters to narrow the results down.
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Practical guidance

Techniques for blood sampling in laboratory animal species to ensure the most appropriate technique is chosen.

Five needles with empty syringes on a pale blue background

Posters and other resources on the use of grimace scales to assess pain in laboratory animals.

The mouse, rat and rabbit grimace scale posters layered over each other.

Resources on rat tickling and how it can be used to promote positive human-animal interactions.

A white rat in a clear plastic cage with wooden shavings, being tickled by a gloved hand.

Learn more about why the single-use of needles should be standard practice and how to implement this in your facility.

Illustration of three needles with low dead space, which would be appropriate for single use.
Bespoke feedback on your experimental plan

The Experimental Design Assistant

Use our free online tool to design your experiments to make them more likely to yield reliable and reproducible results.

Get started
A diagram showing how the EDA can be used to represent a two group comparison experiment. The EDA works by dragging and dropping 'nodes' which appear as coloured shapes. These are then connected with arrows or ‘links’ showing how different parts of an experiment relate to each other. The EDA then uses computer-based logical reasoning to provide feedback on the experimental design.