Replacement, Reduction and Refinement
Guidelines, practical information, publications, video and training materials to help you put the 3Rs into practice.
We fund world class researchers to develop predictive, reliable and humane 3Rs approaches.
Details of NC3Rs projects, including grants, early career awards and work led by our staff.
What are the 3Rs? How many animals are used in research? Find answers to these questions and more.
Latest news
We have received funding from the Bill & Melinda Gates Foundation to support the adoption of 3Rs approaches in biologics batch release testing.
The latest impact stories feature a model of early-stage lung cancer, an artificial human blood vessel to study blood clotting in vitro and a 3D human cell culture model to evaluate and screen treatments for glioblastoma.
Embedding the skills and knowledge needed to develop replacement technologies in the training of early career researchers.
Upcoming events
A live demonstration of the Experimental Design Assistant (EDA), online software to help researchers design robust in vivo experiments
A live demonstration of the Experimental Design Assistant (EDA), online software to help researchers design robust in vivo experiments.
Discover 3Rs innovations from the NC3Rs
Bringing together expertise from different sectors and disciplines to deliver readily available and easily deployed 3Rs models and tools that are more predictive and cost-effective than current animal models.
