Replacement, Reduction and Refinement
Guidelines, practical information, publications, video and training materials to help you put the 3Rs into practice.
We fund world class researchers to develop predictive, reliable and humane 3Rs approaches.
Details of NC3Rs projects, including grants, early career awards and work led by our staff.
What are the 3Rs? How many animals are used in research? Find answers to these questions and more.
Latest news
Funding of £1.2M is available through this year’s CRACK IT Challenges competition. The two 2022 Challenges encompass animal use in the key areas of endocrine disruption and CAR-T cell therapy.
Increased focused on replacement technologies as well as championing high standards in animal research.
An alternative technology making organ-on-a-chip systems more accessible to labs worldwide has won the 3Rs Prize, awarded by NC3Rs and sponsored by GSK.
Upcoming events
A webinar to launch the 2022 CRACK IT Challenge 42: animal-free tumourigenicity assessment of CAR-T and other genetically modified T cells.
A webinar to launch the CRACK IT Challenge 43 – Thyroid Tox: Development of an in silico model to predict thyroid receptor mediated human endocrine
A webinar hosted by the NC3Rs and BTS highlighting benefits of the microsampling technique.
Developing and implementing an institutional 3Rs strategy
Guidance for those overseeing animal research at institutions on recognising 3Rs opportunities and putting them into practice.
