New ARRIVE guidelines 2.0 released
The guidelines and accompanying website will help researchers increase the reliability and reproducibility of animal studies through better reporting.
The NC3Rs and the 3Rs during COVID-19
An update on what we are doing to support the research community.
NC3Rs webinars
Register for our upcoming webinars and watch recordings of past presentations on a wide range of 3Rs topics.
2020 CRACK IT Challenges Competition now open
Read about this year's Challenges and learn how you can apply.
The 3Rs across Europe: webinar series recordings
Watch talks on the latest 3Rs advances from researchers representing six European 3Rs centres.
Re-starting mouse breeding after lockdown?
Visit our breeding and colony management hub for guidance on re-establishing colonies.
Do you want to adopt a new 3Rs approach or transfer your method to another lab?
Apply for an NC3Rs Skills and Knowledge Transfer Award – submit your informal outline by 4pm on Friday 27 November.
3Rs for the public
Learn more about the 3Rs and their importance in research.
Help us fund the best 3Rs research
Apply to join one of our Funding Panels by 4pm on 17 November.
Reducing animal use in the testing of biologicals
New project will review WHO guidelines to identify opportunities to incorporate non-animal testing approaches.
Videos: non-aversive mouse handling in practice
Hear from animal care staff championing non-aversive mouse handling in their facilities.
Experimental design
Resources to help you improve the design and reporting of your in vivo research.

The NC3Rs: Pioneering better science


We help the research community use the latest science and technology to replace animal studies, providing new approaches for biomedical research and avoiding the time and cost associated with in vivo models. Where the use of animals is still required, we support researchers to design the best experiments so that their methods and findings are robust and reproducible. We provide information and guidance on the latest knowledge to improve laboratory animal welfare.

Keep in touch

Latest news

Tunnel handling improves the welfare of mice undergoing repeated procedures

Research shows that the welfare benefits of non-aversive handling persist after repeated restraint, IP injection and anaesthesia.

The 3Rs across Europe: Webinar series

To celebrate the 3Rs in Europe six organisations have come together to organise a virtual event to highlight the latest 3Rs opportunities. 

£2.4 million awarded to support the development of new 3Rs approaches

Our latest round of project grant funding includes three awards bringing 3Rs approaches to veterinary research.

What could an NC3Rs Training Fellowship do for you?

Dr Deepali Pal shares her experiences as an NC3Rs Training Fellow and how the scheme helped her secure an independent position.