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New funding scheme: £4M available for proposals to establish infrastructure needed to accelerate use of non-animal methods. Apply now.

NC3Rs | 20 Years: Pioneering Better Science
Pioneering better science

Replacement, Reduction and Refinement

A UK-based scientific organisation dedicated to helping the research community worldwide to identify, develop and use 3Rs technologies and approaches.
Our mission
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Guidelines, practical information, publications, video and training materials to help you put the 3Rs into practice.

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We fund world class researchers to develop predictive, reliable and humane 3Rs approaches.

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Details of NC3Rs projects, including grants, early career awards and work led by our staff.

Two researchers look at a sample in a Petri dish

What are the 3Rs? How many animals are used in research? Find answers to these questions and more.

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Latest news

We are launching a new funding opportunity through a strategic collaboration with BBSRC to help researchers commercialise their 3Rs tools and technologies.

ICURe Innovate UK and BBSRC

NC3Rs Programme Manager Dr Elliot Lilley reflects on the united vision that drove the success of our project to embed the 3Rs in quality, safety and efficacy testing of vaccines and biological therapeutics.

Portrait of Dr Elliot Lilley

We are partnering with Pint of Science to invite you to learn more about the science behind replacing animals in research.

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Hear from the NC3Rs NAMs Advisory Group as they discuss their recent paper on how to overcome the hurdles to embedding new approach methodologies (NAMs) in chemical and drug safety assessment.

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Bringing together oncology researchers to establish collaborations and catalyse the uptake of 3Rs technologies for cancer research.

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CRACK IT

Discover 3Rs innovations from the NC3Rs

Bringing together expertise from different sectors and disciplines to deliver readily available and easily deployed 3Rs models and tools that are more predictive and cost-effective than current animal models.

Discover our CRACK IT Challenges funding competition
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