Revision of the ARRIVE guidelines
The revised ARRIVE guidelines are now available in preprint – sign up as a roadtester and help shape their final development.
Burrow into our new citizen science project
Contribute to lab mouse welfare via this project, a collaboration with MRC Harwell.
Explore our new Innovation Platform website
The new website features a refreshed design, showcasing our CRACK IT programme.
Could you be the next Chair of the NC3Rs Board?
We're recruiting a new Chair to help shape our strategy and promote the UK as a world leader in 3Rs research. Apply by 4pm on Tuesday 27 August.
What are the 3Rs and why are they important?
Our new video presentation has been designed for use in training and education.
Discover publications from NC3Rs researchers
Visit our open access publication portal, hosted by F1000Research.
2019 CRACK IT Challenges announced
Learn more about this year's competition, including our launch event in September.
Tech3Rs: our animal technician newsletter
Sign up to receive free copies for UK facilities and stay up to date with the 3Rs.
2019 NC3Rs/IAT Animal Technicians’ Symposium
A chance for junior animal technicians to learn about the latest advances in refinement.
Explore the evidence base for refined mouse handling
Our new printable table summarises the research published to-date on tunnel handling and cupping methods.
Experimental design
Resources to help you improve the design and reporting of your in vivo research.
Single use needles: putting refinement into practice
Dr Sally Robinson explores how AstraZeneca has implemented the single use of needles.

The NC3Rs: Pioneering better science

If you are a scientist, animal technician, veterinarian, regulator, funder or policy maker, the NC3Rs can help you to:

  • Drive scientific and technological developments that replace, reduce or refine the use of animals in research (the 3Rs)
  • Ensure your animal experiments are as robust and reproducible as possible
  • Provide the best welfare for laboratory animals


Science-led and evidence-based, we fund research and early careers, foster collaborations between universities and industry to develop and commercialise 3Rs technologies, and provide information on the latest advances to put the 3Rs into practice.

Keep in touch

Latest news & blogs

Help us discover more about the secret lives of mice

Our new citizen science project gives anyone the chance to get involved in improving laboratory mouse welfare – project volunteer Emma Robinson explains how.

New e-learning modules on laboratory animal anaesthesia

The new modules, which focus on pre-anaesthetic preparations and choosing an anaesthetic, are the first in a series that will address the learning outcomes of module EU21.

2019 CRACK IT Challenges announced

£2.5M is available for this year’s R&D competition, with funding available to solve three Challenges.

A new automated behaviour monitoring tool for zebrafish

The Fish Behaviour Index uses a camera and tracking software to assess how zebrafish behaviour changes in response to laboratory procedures.

A taste of Pint of Science 2019

We look back at the events we sponsored in Birmingham, London and Newcastle as part of Pint of Science 2019, which featured NC3Rs-funded researchers from a variety of fields speaking about their work.

Single use needles: putting refinement into practice

In this guest blog post, Dr Sally Robinson explores how AstraZeneca has implemented the single use of needles as a refinement across their sites.