Registration Details
The NC3Rs Virtual Second Species CRACK IT Challenge is exploiting advances in computational approaches and machine learning to develop a 'Virtual Dog' – ultimately aiming replace the dog in chronic toxicity studies. We awarded ESQlabs £1.6M to deliver the Challenge, which is sponsored by seven pharmaceutical industry Sponsors from the UK, mainland Europe and North America and delivered in partnership with eTransafe.
In this webinar co-hosted with the Health and Environmental Sciences Institute (HESI), the team from ESQlabs will present their progress in developing computational modelling approaches to predict toxicological outcomes and reduce reliance on the use of dogs in safety assessment. The presentation will provide an overview of recent scientific advances, key findings, ongoing challenges and next steps in the project, with a focus on the potential application of these approaches to support improved safety assessments.
About the Virtual Second Species Challenge
The aim of the Virtual Second Species CRACK IT Challenge is to apply advanced computational and mathematical modelling approaches to develop a ‘Virtual Dog’ that can be used to model toxicological endpoints for new chemical entities. The Challenge builds on work from the NC3Rs toxicology programme that, in collaboration with over 30 pharmaceutical companies and regulatory bodies, analysed the use of two species in regulatory toxicology and identified opportunities to use a single rodent species for certain drug modalities.